Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER
Enhancing the sensitivity of nuclear magnetic resonance (NMR) technology has been the focus of NMR research for decades, which offers the potential to significantly expand its applications in chemistry, biology, and medical imaging. Parahydrogen-induced polarization (PHIP) emerges as a cost-effectiv...
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KeAi Communications Co. Ltd.
2025-02-01
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| Series: | Magnetic Resonance Letters |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772516224000445 |
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| author | Zeyu Zheng Qiwei Peng Huijun Sun Xinchang Wang Zhong Chen |
| author_facet | Zeyu Zheng Qiwei Peng Huijun Sun Xinchang Wang Zhong Chen |
| author_sort | Zeyu Zheng |
| collection | DOAJ |
| description | Enhancing the sensitivity of nuclear magnetic resonance (NMR) technology has been the focus of NMR research for decades, which offers the potential to significantly expand its applications in chemistry, biology, and medical imaging. Parahydrogen-induced polarization (PHIP) emerges as a cost-effective approach to substantially enhance the sensitivity of NMR. Nevertheless, the amplification of the 1H signal in PHIP is susceptible to interference from the thermal polarization state 1H NMR signal. Employing RASER (radiofrequency amplification by stimulated emission of radiation) proves effective in mitigating such interference, which can reduce the linewidth and increase the sensitivity at the same time. In this work, we utilized PHIP and RASER to enhance the signal-to-noise ratio (SNR) of a series of biocompatible alkynyl organic acid molecules. The alkynyl acid with the highest enhancement factor was first identified through PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment) experiments. Subsequently, RASER experiments were carried out through hyperpolarization of 5-hexynoic acid, exploring its signal characteristics under varying flow rates and pressures. The SNR of proton signals of 5-hexynoic acid surpassed 150,000, an 18.62-fold improvement compared with traditional hyperpolarized signals in PASADENA, and a markedly narrowed linewidth of 0.06 Hz. |
| format | Article |
| id | doaj-art-d237d52ed7e647cc9188e31e473a7afb |
| institution | DOAJ |
| issn | 2772-5162 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Magnetic Resonance Letters |
| spelling | doaj-art-d237d52ed7e647cc9188e31e473a7afb2025-08-20T02:57:33ZengKeAi Communications Co. Ltd.Magnetic Resonance Letters2772-51622025-02-015120013710.1016/j.mrl.2024.200137Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASERZeyu Zheng0Qiwei Peng1Huijun Sun2Xinchang Wang3Zhong Chen4Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, Xiamen, 361005, ChinaFujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, Xiamen, 361005, ChinaFujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, Xiamen, 361005, ChinaFujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, Xiamen, 361005, China; State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, China; Corresponding author. Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, Xiamen, 361005, China.Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, Xiamen, 361005, China; State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, China; Corresponding author. Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, Xiamen, 361005, China.Enhancing the sensitivity of nuclear magnetic resonance (NMR) technology has been the focus of NMR research for decades, which offers the potential to significantly expand its applications in chemistry, biology, and medical imaging. Parahydrogen-induced polarization (PHIP) emerges as a cost-effective approach to substantially enhance the sensitivity of NMR. Nevertheless, the amplification of the 1H signal in PHIP is susceptible to interference from the thermal polarization state 1H NMR signal. Employing RASER (radiofrequency amplification by stimulated emission of radiation) proves effective in mitigating such interference, which can reduce the linewidth and increase the sensitivity at the same time. In this work, we utilized PHIP and RASER to enhance the signal-to-noise ratio (SNR) of a series of biocompatible alkynyl organic acid molecules. The alkynyl acid with the highest enhancement factor was first identified through PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment) experiments. Subsequently, RASER experiments were carried out through hyperpolarization of 5-hexynoic acid, exploring its signal characteristics under varying flow rates and pressures. The SNR of proton signals of 5-hexynoic acid surpassed 150,000, an 18.62-fold improvement compared with traditional hyperpolarized signals in PASADENA, and a markedly narrowed linewidth of 0.06 Hz.http://www.sciencedirect.com/science/article/pii/S2772516224000445Nuclear magnetic resonanceParahydrogen-induced polarizationPASADENARASERAlkynyl acid |
| spellingShingle | Zeyu Zheng Qiwei Peng Huijun Sun Xinchang Wang Zhong Chen Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER Magnetic Resonance Letters Nuclear magnetic resonance Parahydrogen-induced polarization PASADENA RASER Alkynyl acid |
| title | Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER |
| title_full | Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER |
| title_fullStr | Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER |
| title_full_unstemmed | Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER |
| title_short | Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER |
| title_sort | spontaneous increasing of sensitivity and resolution in parahydrogen induced hyperpolarization by raser |
| topic | Nuclear magnetic resonance Parahydrogen-induced polarization PASADENA RASER Alkynyl acid |
| url | http://www.sciencedirect.com/science/article/pii/S2772516224000445 |
| work_keys_str_mv | AT zeyuzheng spontaneousincreasingofsensitivityandresolutioninparahydrogeninducedhyperpolarizationbyraser AT qiweipeng spontaneousincreasingofsensitivityandresolutioninparahydrogeninducedhyperpolarizationbyraser AT huijunsun spontaneousincreasingofsensitivityandresolutioninparahydrogeninducedhyperpolarizationbyraser AT xinchangwang spontaneousincreasingofsensitivityandresolutioninparahydrogeninducedhyperpolarizationbyraser AT zhongchen spontaneousincreasingofsensitivityandresolutioninparahydrogeninducedhyperpolarizationbyraser |