Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog
An 8-year-old neutered male Greyhound was presented with intermittent lameness and joint pain, leading to a diagnosis of idiopathic immune-mediated polyarthritis. The initial treatment regimen involved prednisone and minocycline. Leflunomide (3 mg/kg PO q24h) was prescribed later for secondary immun...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1529324/full |
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| author | Cristina Aponte-Colon Lauren A. Cochran Lauren Harris Erick A. Mears Steven W. Frederick |
| author_facet | Cristina Aponte-Colon Lauren A. Cochran Lauren Harris Erick A. Mears Steven W. Frederick |
| author_sort | Cristina Aponte-Colon |
| collection | DOAJ |
| description | An 8-year-old neutered male Greyhound was presented with intermittent lameness and joint pain, leading to a diagnosis of idiopathic immune-mediated polyarthritis. The initial treatment regimen involved prednisone and minocycline. Leflunomide (3 mg/kg PO q24h) was prescribed later for secondary immune modulation. Five weeks later, the dog exhibited signs of acute lethargy, weakness, and increased liver enzyme activities (alanine aminotransferase [ALT] 6,613 U/L and aspartate aminotransferase [AST] 3,718 U/L). Despitereceiving supportive care, the dog died. Necropsy revealed massive hepatic necrosis with effaced hepatic architecture and centrilobular pools of free blood, similar to findings noted in people with leflunomide-induced hepatic injury. This case highlights a previously unreported severe, idiosyncratic hepatotoxicity associated with standard doses of leflunomide in dogs, illustrating the need for vigilant monitoring and increased awareness of the potential need for dose adjustment if liver enzyme elevations occur. |
| format | Article |
| id | doaj-art-d2377eb36fb747feaa57389ab1d9bbb5 |
| institution | DOAJ |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-d2377eb36fb747feaa57389ab1d9bbb52025-08-20T02:57:13ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-05-011210.3389/fvets.2025.15293241529324Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dogCristina Aponte-Colon0Lauren A. Cochran1Lauren Harris2Erick A. Mears3Steven W. Frederick4Blue Pearl Veterinary Partners, Tampa, FL, United StatesBlue Pearl Veterinary Partners, Tampa, FL, United StatesBlue Pearl Veterinary Partners, Tampa, FL, United StatesBlue Pearl Veterinary Partners, Tampa, FL, United StatesBlue Pearl Veterinary Science, Atlanta, GA, United StatesAn 8-year-old neutered male Greyhound was presented with intermittent lameness and joint pain, leading to a diagnosis of idiopathic immune-mediated polyarthritis. The initial treatment regimen involved prednisone and minocycline. Leflunomide (3 mg/kg PO q24h) was prescribed later for secondary immune modulation. Five weeks later, the dog exhibited signs of acute lethargy, weakness, and increased liver enzyme activities (alanine aminotransferase [ALT] 6,613 U/L and aspartate aminotransferase [AST] 3,718 U/L). Despitereceiving supportive care, the dog died. Necropsy revealed massive hepatic necrosis with effaced hepatic architecture and centrilobular pools of free blood, similar to findings noted in people with leflunomide-induced hepatic injury. This case highlights a previously unreported severe, idiosyncratic hepatotoxicity associated with standard doses of leflunomide in dogs, illustrating the need for vigilant monitoring and increased awareness of the potential need for dose adjustment if liver enzyme elevations occur.https://www.frontiersin.org/articles/10.3389/fvets.2025.1529324/fullcase reportimmune-mediatedpolyarthritisIMPAliver enzyme |
| spellingShingle | Cristina Aponte-Colon Lauren A. Cochran Lauren Harris Erick A. Mears Steven W. Frederick Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog Frontiers in Veterinary Science case report immune-mediated polyarthritis IMPA liver enzyme |
| title | Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog |
| title_full | Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog |
| title_fullStr | Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog |
| title_full_unstemmed | Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog |
| title_short | Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog |
| title_sort | case report fatal presumptive idiosyncratic hepatic necrosis secondary to standard dose leflunomide administration in a dog |
| topic | case report immune-mediated polyarthritis IMPA liver enzyme |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1529324/full |
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