RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice
Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease and gout. Probiotics have the potential effect of alleviating HUA. The purpose of this study was to screen probiotics with UA-lowering activity and explore the underly...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.940228/full |
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| author | Jiayuan Cao Qiqi Liu Haining Hao Yushan Bu Xiaoying Tian Ting Wang Huaxi Yi |
| author_facet | Jiayuan Cao Qiqi Liu Haining Hao Yushan Bu Xiaoying Tian Ting Wang Huaxi Yi |
| author_sort | Jiayuan Cao |
| collection | DOAJ |
| description | Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease and gout. Probiotics have the potential effect of alleviating HUA. The purpose of this study was to screen probiotics with UA-lowering activity and explore the underlying mechanism. The UA-lowering activity of 20 lactic acid bacteria strains was investigated in vitro, and the effect of candidate probiotics on UA metabolism was evaluated using the HUA Balb/c mouse model. The results showed that Lactobacillus paracasei X11 had excellent UA-lowering activity in vitro, which could degrade nucleotides and nucleosides completely within 30 min, and the degradation rates of purine and trioxypurine could reach 83.25% and 80.42%, respectively. In addition, oral administration of L. paracasei X11 could reduce serum UA by 52.45% and inhibit renal proinflammatory cytokine IL-1β by 50.69%, regulating adenosine deaminase (ADA), xanthine oxidase (XOD), and transporter expression (GLUT9, NPT1, and URAT1) to a normal level. Moreover, it could restore the ratio of Bacteroidetes to Firmicutes (Bac/Firm ratio) and showed a positive effect on the recovery of the intestinal microbiota. These findings provided fundamental information about the UA-lowering properties of probiotics, which suggested that L. paracasei X11 had the potential to be developed as a novel probiotic strain to ameliorate HUA. |
| format | Article |
| id | doaj-art-d237276c983e42de8d722a8120ade3d4 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-d237276c983e42de8d722a8120ade3d42025-08-20T02:12:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.940228940228RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in MiceJiayuan CaoQiqi LiuHaining HaoYushan BuXiaoying TianTing WangHuaxi YiHyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease and gout. Probiotics have the potential effect of alleviating HUA. The purpose of this study was to screen probiotics with UA-lowering activity and explore the underlying mechanism. The UA-lowering activity of 20 lactic acid bacteria strains was investigated in vitro, and the effect of candidate probiotics on UA metabolism was evaluated using the HUA Balb/c mouse model. The results showed that Lactobacillus paracasei X11 had excellent UA-lowering activity in vitro, which could degrade nucleotides and nucleosides completely within 30 min, and the degradation rates of purine and trioxypurine could reach 83.25% and 80.42%, respectively. In addition, oral administration of L. paracasei X11 could reduce serum UA by 52.45% and inhibit renal proinflammatory cytokine IL-1β by 50.69%, regulating adenosine deaminase (ADA), xanthine oxidase (XOD), and transporter expression (GLUT9, NPT1, and URAT1) to a normal level. Moreover, it could restore the ratio of Bacteroidetes to Firmicutes (Bac/Firm ratio) and showed a positive effect on the recovery of the intestinal microbiota. These findings provided fundamental information about the UA-lowering properties of probiotics, which suggested that L. paracasei X11 had the potential to be developed as a novel probiotic strain to ameliorate HUA.https://www.frontiersin.org/articles/10.3389/fimmu.2022.940228/fullhyperuricemiauric acid-loweringLactobacillus paracasei X11gut microbiotaameliorating |
| spellingShingle | Jiayuan Cao Qiqi Liu Haining Hao Yushan Bu Xiaoying Tian Ting Wang Huaxi Yi RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice Frontiers in Immunology hyperuricemia uric acid-lowering Lactobacillus paracasei X11 gut microbiota ameliorating |
| title | RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice |
| title_full | RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice |
| title_fullStr | RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice |
| title_full_unstemmed | RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice |
| title_short | RETRACTED: Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice |
| title_sort | retracted lactobacillus paracasei x11 ameliorates hyperuricemia and modulates gut microbiota in mice |
| topic | hyperuricemia uric acid-lowering Lactobacillus paracasei X11 gut microbiota ameliorating |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.940228/full |
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