Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database
Abstract Knowledge of patients with gastrointestinal leiomyosarcoma (GILMS) is lacking. In this study, we aimed to clarify the disease features and prognosis of GILMS based on the Surveillance, Epidemiology, and End Results database. The clinicopathological, treatment, survival, and prognostic data...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-91758-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850251775367446528 |
|---|---|
| author | Yanan Bao Xudong Yang Quanming Zhao Wenliang Li |
| author_facet | Yanan Bao Xudong Yang Quanming Zhao Wenliang Li |
| author_sort | Yanan Bao |
| collection | DOAJ |
| description | Abstract Knowledge of patients with gastrointestinal leiomyosarcoma (GILMS) is lacking. In this study, we aimed to clarify the disease features and prognosis of GILMS based on the Surveillance, Epidemiology, and End Results database. The clinicopathological, treatment, survival, and prognostic data of GILMS from 2000–2020 were retrieved. Appropriate statistical approaches were used to evaluate demographic characteristics and survival outcomes. A total of 479 individuals with GILMS met the screening criteria. The median age of patients was 64 (15–90) years. Only 7.9% of these cases were diagnosed with lymph node metastasis. T2 or higher primary tumor extension was diagnosed in 78.1% of the patients. The 5-year cancer-specific survival (CSS) of patients who had and had not undergone surgery was 66.5% and 0%, respectively. Multivariate Cox proportional hazards analysis based on overall survival and CSS showed that female sex was a significant independent protective factor. Significant independent risk factors included age 65–79, age ≥ 80, poor differentiation, T2 and higher T stage, distant metastasis, and no surgery. Neither chemotherapy nor radiotherapy influenced survival or prognosis. This comprehensive analysis underscored the necessity of surgical excision for prolonging survival times and highlighted the urgent need to explore effective systematic treatments. |
| format | Article |
| id | doaj-art-d23463d09e6c4359b11e1b7c5f4e243a |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d23463d09e6c4359b11e1b7c5f4e243a2025-08-20T01:57:49ZengNature PortfolioScientific Reports2045-23222025-03-0115111410.1038/s41598-025-91758-7Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER databaseYanan Bao0Xudong Yang1Quanming Zhao2Wenliang Li3Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Kunming Medical UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical UniversityDepartment of Gastrointestinal Surgery, The Third Affiliated Hospital of Kunming Medical UniversityDepartment of Gastrointestinal Surgery, The Third Affiliated Hospital of Kunming Medical UniversityAbstract Knowledge of patients with gastrointestinal leiomyosarcoma (GILMS) is lacking. In this study, we aimed to clarify the disease features and prognosis of GILMS based on the Surveillance, Epidemiology, and End Results database. The clinicopathological, treatment, survival, and prognostic data of GILMS from 2000–2020 were retrieved. Appropriate statistical approaches were used to evaluate demographic characteristics and survival outcomes. A total of 479 individuals with GILMS met the screening criteria. The median age of patients was 64 (15–90) years. Only 7.9% of these cases were diagnosed with lymph node metastasis. T2 or higher primary tumor extension was diagnosed in 78.1% of the patients. The 5-year cancer-specific survival (CSS) of patients who had and had not undergone surgery was 66.5% and 0%, respectively. Multivariate Cox proportional hazards analysis based on overall survival and CSS showed that female sex was a significant independent protective factor. Significant independent risk factors included age 65–79, age ≥ 80, poor differentiation, T2 and higher T stage, distant metastasis, and no surgery. Neither chemotherapy nor radiotherapy influenced survival or prognosis. This comprehensive analysis underscored the necessity of surgical excision for prolonging survival times and highlighted the urgent need to explore effective systematic treatments.https://doi.org/10.1038/s41598-025-91758-7ChemotherapyGastrointestinal leiomyosarcomasRadiotherapySEERSurgery |
| spellingShingle | Yanan Bao Xudong Yang Quanming Zhao Wenliang Li Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database Scientific Reports Chemotherapy Gastrointestinal leiomyosarcomas Radiotherapy SEER Surgery |
| title | Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database |
| title_full | Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database |
| title_fullStr | Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database |
| title_full_unstemmed | Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database |
| title_short | Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database |
| title_sort | analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the seer database |
| topic | Chemotherapy Gastrointestinal leiomyosarcomas Radiotherapy SEER Surgery |
| url | https://doi.org/10.1038/s41598-025-91758-7 |
| work_keys_str_mv | AT yananbao analysisofdemographicsandtreatmentoutcomesforgastrointestinalleiomyosarcomabasedontheseerdatabase AT xudongyang analysisofdemographicsandtreatmentoutcomesforgastrointestinalleiomyosarcomabasedontheseerdatabase AT quanmingzhao analysisofdemographicsandtreatmentoutcomesforgastrointestinalleiomyosarcomabasedontheseerdatabase AT wenliangli analysisofdemographicsandtreatmentoutcomesforgastrointestinalleiomyosarcomabasedontheseerdatabase |