Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease
Abstract Introduction Celiac disease (CD) affects the small intestine, leading to a progressive disappearance of intestinal villi, and can be found in association with several other autoimmune and inflammatory conditions. The main objective of this study was to determine the prevalence and the clini...
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Adis, Springer Healthcare
2025-01-01
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| Series: | Rheumatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40744-024-00741-7 |
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| author | Eléonore Bettacchioli Divi Cornec Pauline Gardien Lucille Quenehervé Dewi Guellec Alice Tison Arnaud Constantin Thierry Lequerre Clothilde Bideau Anne Lise André Clément Capaldo Valérie Devauchelle-Pensec Maryvonne Dueymes Alain Saraux |
| author_facet | Eléonore Bettacchioli Divi Cornec Pauline Gardien Lucille Quenehervé Dewi Guellec Alice Tison Arnaud Constantin Thierry Lequerre Clothilde Bideau Anne Lise André Clément Capaldo Valérie Devauchelle-Pensec Maryvonne Dueymes Alain Saraux |
| author_sort | Eléonore Bettacchioli |
| collection | DOAJ |
| description | Abstract Introduction Celiac disease (CD) affects the small intestine, leading to a progressive disappearance of intestinal villi, and can be found in association with several other autoimmune and inflammatory conditions. The main objective of this study was to determine the prevalence and the clinical significance of anti-transglutaminase and anti-endomysium antibodies in patients diagnosed with early rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods We measured anti-transglutaminase and anti-endomysium antibodies in biobanked serum samples at inclusion in two French prospective multicenter cohorts of patients with suspected early rheumatoid arthritis (ESPOIR, n = 713) and spondyloarthritis (DESIR, n = 709). Results were compared with the clinical, laboratory, and radiographic findings obtained in patients during a 10-year follow-up period. Results In the DESIR cohort, anti-transglutaminase antibodies were evidenced at low levels (less than three times the upper limit of normal) in 2/709 (0.42%) patients and anti-endomysium antibodies in 0/709 (0%). In the ESPOIR cohort, anti-transglutaminase antibodies were evidenced in 6/713 (0.84%) patients and anti-endomysium antibodies in 1/713 (0.14%). Only the latter patient was confirmed to have celiac disease. Interestingly, this patient was ultimately diagnosed with Sjögren’s disease, an autoimmune condition known to be associated with an increased risk of celiac disease. Conclusion The very low identified prevalence of anti-transglutaminase and anti-endomysium antibodies suggests a negligible risk of celiac disease in patients with early-stage RA or SpA, which are among the most common inflammatory rheumatic conditions. Consequently, routine screening for celiac disease via these antibodies in patients presenting with early inflammatory rheumatic conditions should not be performed except in case of clinical suspicion of celiac disease. |
| format | Article |
| id | doaj-art-d232a10d3b1e4eae92a1223c29e07e7c |
| institution | DOAJ |
| issn | 2198-6576 2198-6584 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Adis, Springer Healthcare |
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| series | Rheumatology and Therapy |
| spelling | doaj-art-d232a10d3b1e4eae92a1223c29e07e7c2025-08-20T02:41:35ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842025-01-0112237138010.1007/s40744-024-00741-7Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint DiseaseEléonore Bettacchioli0Divi Cornec1Pauline Gardien2Lucille Quenehervé3Dewi Guellec4Alice Tison5Arnaud Constantin6Thierry Lequerre7Clothilde Bideau8Anne Lise André9Clément Capaldo10Valérie Devauchelle-Pensec11Maryvonne Dueymes12Alain Saraux13LBAI, UMR1227, Univ BrestLBAI, UMR1227, Univ BrestLBAI, UMR1227, Univ BrestDepartment of Gastroenterology, CHU de BrestDepartment of Rheumatology, CHU de BrestLBAI, UMR1227, Univ BrestDepartment of Rheumatology, CHU de Toulouse, Pierre-Paul Riquet University Hospital, Toulouse III–Paul Sabatier University, INFINITY, INSERM UMR 1291CHU de RouenLBAI, UMR1227, Univ BrestLBAI, UMR1227, Univ BrestDepartment of Biochemistry, CHU de BrestLBAI, UMR1227, Univ BrestLBAI, UMR1227, Univ BrestLBAI, UMR1227, Univ BrestAbstract Introduction Celiac disease (CD) affects the small intestine, leading to a progressive disappearance of intestinal villi, and can be found in association with several other autoimmune and inflammatory conditions. The main objective of this study was to determine the prevalence and the clinical significance of anti-transglutaminase and anti-endomysium antibodies in patients diagnosed with early rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods We measured anti-transglutaminase and anti-endomysium antibodies in biobanked serum samples at inclusion in two French prospective multicenter cohorts of patients with suspected early rheumatoid arthritis (ESPOIR, n = 713) and spondyloarthritis (DESIR, n = 709). Results were compared with the clinical, laboratory, and radiographic findings obtained in patients during a 10-year follow-up period. Results In the DESIR cohort, anti-transglutaminase antibodies were evidenced at low levels (less than three times the upper limit of normal) in 2/709 (0.42%) patients and anti-endomysium antibodies in 0/709 (0%). In the ESPOIR cohort, anti-transglutaminase antibodies were evidenced in 6/713 (0.84%) patients and anti-endomysium antibodies in 1/713 (0.14%). Only the latter patient was confirmed to have celiac disease. Interestingly, this patient was ultimately diagnosed with Sjögren’s disease, an autoimmune condition known to be associated with an increased risk of celiac disease. Conclusion The very low identified prevalence of anti-transglutaminase and anti-endomysium antibodies suggests a negligible risk of celiac disease in patients with early-stage RA or SpA, which are among the most common inflammatory rheumatic conditions. Consequently, routine screening for celiac disease via these antibodies in patients presenting with early inflammatory rheumatic conditions should not be performed except in case of clinical suspicion of celiac disease.https://doi.org/10.1007/s40744-024-00741-7SpondyloarthritisRheumatoid arthritisCeliac diseaseAnti-transglutaminase IgAAnti-endomysiumEpidemiology |
| spellingShingle | Eléonore Bettacchioli Divi Cornec Pauline Gardien Lucille Quenehervé Dewi Guellec Alice Tison Arnaud Constantin Thierry Lequerre Clothilde Bideau Anne Lise André Clément Capaldo Valérie Devauchelle-Pensec Maryvonne Dueymes Alain Saraux Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease Rheumatology and Therapy Spondyloarthritis Rheumatoid arthritis Celiac disease Anti-transglutaminase IgA Anti-endomysium Epidemiology |
| title | Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease |
| title_full | Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease |
| title_fullStr | Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease |
| title_full_unstemmed | Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease |
| title_short | Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease |
| title_sort | prevalence and significance of the presence of anti transglutaminase and anti endomysium antibodies in patients with early inflammatory joint disease |
| topic | Spondyloarthritis Rheumatoid arthritis Celiac disease Anti-transglutaminase IgA Anti-endomysium Epidemiology |
| url | https://doi.org/10.1007/s40744-024-00741-7 |
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