NAD + metabolism and function in innate and adaptive immune cells
Abstract Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with implications for our understanding of immune homeo...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | Journal of Inflammation |
| Online Access: | https://doi.org/10.1186/s12950-025-00457-7 |
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| _version_ | 1849767020553306112 |
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| author | Rebecca Mann Victoria Stavrou Sarah Dimeloe |
| author_facet | Rebecca Mann Victoria Stavrou Sarah Dimeloe |
| author_sort | Rebecca Mann |
| collection | DOAJ |
| description | Abstract Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with implications for our understanding of immune homeostasis, inflammation, and disease. This review reports our current understanding on the role of NAD + in the immune system, specifically in macrophages and T cells, facilitating their metabolic reprogramming during differentiation and activation. It offers an overview of NAD + biosynthesis within these immune cells, describes its role in the modulation of immune cell metabolism and effector function, and highlights potential therapeutic applications of NAD + modulation in immunological disorders including autoimmune diseases and cancer. |
| format | Article |
| id | doaj-art-d230e062bca545ab89b525d6ce6ef5d6 |
| institution | DOAJ |
| issn | 1476-9255 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj-art-d230e062bca545ab89b525d6ce6ef5d62025-08-20T03:04:22ZengBMCJournal of Inflammation1476-92552025-08-012211910.1186/s12950-025-00457-7NAD + metabolism and function in innate and adaptive immune cellsRebecca Mann0Victoria Stavrou1Sarah Dimeloe2Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of BirminghamDepartment of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of BirminghamDepartment of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of BirminghamAbstract Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with implications for our understanding of immune homeostasis, inflammation, and disease. This review reports our current understanding on the role of NAD + in the immune system, specifically in macrophages and T cells, facilitating their metabolic reprogramming during differentiation and activation. It offers an overview of NAD + biosynthesis within these immune cells, describes its role in the modulation of immune cell metabolism and effector function, and highlights potential therapeutic applications of NAD + modulation in immunological disorders including autoimmune diseases and cancer.https://doi.org/10.1186/s12950-025-00457-7 |
| spellingShingle | Rebecca Mann Victoria Stavrou Sarah Dimeloe NAD + metabolism and function in innate and adaptive immune cells Journal of Inflammation |
| title | NAD + metabolism and function in innate and adaptive immune cells |
| title_full | NAD + metabolism and function in innate and adaptive immune cells |
| title_fullStr | NAD + metabolism and function in innate and adaptive immune cells |
| title_full_unstemmed | NAD + metabolism and function in innate and adaptive immune cells |
| title_short | NAD + metabolism and function in innate and adaptive immune cells |
| title_sort | nad metabolism and function in innate and adaptive immune cells |
| url | https://doi.org/10.1186/s12950-025-00457-7 |
| work_keys_str_mv | AT rebeccamann nadmetabolismandfunctionininnateandadaptiveimmunecells AT victoriastavrou nadmetabolismandfunctionininnateandadaptiveimmunecells AT sarahdimeloe nadmetabolismandfunctionininnateandadaptiveimmunecells |