Role of TRAP1 Protein in the Development and Progression of Glioblastoma
Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding the molecular mechanisms involved in the biology of glioblastoma, patient survival rates remain disappointing, primarily due to the lack of effective treatment options. Tumor necro...
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| Language: | English |
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Bashkir State Medical University
2024-12-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/1023 |
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| author | I. F. Gareev A. S. Yasinskaya S. A. Roumiantsev A. A. Bukhvostov |
| author_facet | I. F. Gareev A. S. Yasinskaya S. A. Roumiantsev A. A. Bukhvostov |
| author_sort | I. F. Gareev |
| collection | DOAJ |
| description | Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding the molecular mechanisms involved in the biology of glioblastoma, patient survival rates remain disappointing, primarily due to the lack of effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the heat shock protein 90 (Hsp90) family, refers to a protein predominantly localized in the mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This protein is highly expressed in several types of tumors, including colorectal cancer, breast cancer, prostate cancer, and lung cancer, and is often associated with drug resistance. However, TRAP1 is also downregulated in certain cancers such as ovarian cancer, bladder cancer, and renal cancer, where its lower expression correlates with poorer prognoses and chemoresistance. The role of TRAP1 lies in enhancing or suppressing oxidative phosphorylation, with the impact of such regulation on tumor development and progression being a matter of ongoing debate. These observations prompt further investigation into the mechanisms responsible for the dual role of TRAP1 as both an oncogene and a tumor suppressor in specific types of tumors, particularly glioblastoma. The present study reviews the role of TRAP1 in the development and progression of glioblastoma and discusses the potential of targeting TRAP1 as a novel therapeutic approach against tumors. |
| format | Article |
| id | doaj-art-d22feecf994e4e74a379d9955ee681a8 |
| institution | Kabale University |
| issn | 2076-3093 2307-0501 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj-art-d22feecf994e4e74a379d9955ee681a82025-08-20T03:39:58ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012024-12-0114436938110.24060/2076-3093-2024-14-4-369-381603Role of TRAP1 Protein in the Development and Progression of GlioblastomaI. F. Gareev0A. S. Yasinskaya1S. A. Roumiantsev2A. A. Bukhvostov3Central Research Laboratory, Bashkir State Medical University; Pirogov Russian National Research Medical UniversityClinical Emergency HospitalPirogov Russian National Research Medical University; National Medical Endocrinology Research CentrePirogov Russian National Research Medical UniversityGlioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding the molecular mechanisms involved in the biology of glioblastoma, patient survival rates remain disappointing, primarily due to the lack of effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the heat shock protein 90 (Hsp90) family, refers to a protein predominantly localized in the mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This protein is highly expressed in several types of tumors, including colorectal cancer, breast cancer, prostate cancer, and lung cancer, and is often associated with drug resistance. However, TRAP1 is also downregulated in certain cancers such as ovarian cancer, bladder cancer, and renal cancer, where its lower expression correlates with poorer prognoses and chemoresistance. The role of TRAP1 lies in enhancing or suppressing oxidative phosphorylation, with the impact of such regulation on tumor development and progression being a matter of ongoing debate. These observations prompt further investigation into the mechanisms responsible for the dual role of TRAP1 as both an oncogene and a tumor suppressor in specific types of tumors, particularly glioblastoma. The present study reviews the role of TRAP1 in the development and progression of glioblastoma and discusses the potential of targeting TRAP1 as a novel therapeutic approach against tumors.https://www.surgonco.ru/jour/article/view/1023glioblastomatrap1oncogenesistargeted therapymetabolismstem cellsapoptosis |
| spellingShingle | I. F. Gareev A. S. Yasinskaya S. A. Roumiantsev A. A. Bukhvostov Role of TRAP1 Protein in the Development and Progression of Glioblastoma Креативная хирургия и онкология glioblastoma trap1 oncogenesis targeted therapy metabolism stem cells apoptosis |
| title | Role of TRAP1 Protein in the Development and Progression of Glioblastoma |
| title_full | Role of TRAP1 Protein in the Development and Progression of Glioblastoma |
| title_fullStr | Role of TRAP1 Protein in the Development and Progression of Glioblastoma |
| title_full_unstemmed | Role of TRAP1 Protein in the Development and Progression of Glioblastoma |
| title_short | Role of TRAP1 Protein in the Development and Progression of Glioblastoma |
| title_sort | role of trap1 protein in the development and progression of glioblastoma |
| topic | glioblastoma trap1 oncogenesis targeted therapy metabolism stem cells apoptosis |
| url | https://www.surgonco.ru/jour/article/view/1023 |
| work_keys_str_mv | AT ifgareev roleoftrap1proteininthedevelopmentandprogressionofglioblastoma AT asyasinskaya roleoftrap1proteininthedevelopmentandprogressionofglioblastoma AT saroumiantsev roleoftrap1proteininthedevelopmentandprogressionofglioblastoma AT aabukhvostov roleoftrap1proteininthedevelopmentandprogressionofglioblastoma |