Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury—a randomized, double-blind, and placebo-controlled pilot study

Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury—a randomized, double-blind, and placebo-controlled pilot study

BackgroundHigh-dose testosterone replacement therapy (TRT), paired with finasteride (type II 5α-reductase inhibitor), improves body composition, muscle strength, and bone mineral density (BMD) in older men, without inducing prostate enlargement—a side effect associated with TRT. Men with spinal cord...

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Bibliographic Details
Main Authors: Dana M. Otzel, Larissa Nichols, Christine F. Conover, Stephen A. Marangi, Jayachandra R. Kura, Dominic K. Iannaccone, David J. Clark, Chris M. Gregory, Christopher F. Sonntag, Anita Wokhlu, Hans K. Ghayee, Michael J. McPhaul, Charles E. Levy, Charles A. Plumlee, Robert B. Sammel, Kevin T. White, Joshua F. Yarrow
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Neurology
Subjects:
androgen
estrogen
testosterone replacement
hypogonadism
spinal cord injury
muscle
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1479264/full
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