Biosynthesis and characterization of Cu-Se bimetallic nanoparticles: an effective approach as anticancer agents
Bimetallic nanoparticles (BNPs) have garnered a great interest rather than monometallic nanoparticles (NPs) in terms of biotechnological applications due to their enhanced properties. They have a growing interest as promising biomedical agents for drug delivery, antibacterial, and anticancer trea...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2024-10-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_387285_53fdd036b52fcf8dd925abc9a09ff865.pdf |
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| Summary: | Bimetallic nanoparticles (BNPs) have garnered a great interest rather than monometallic
nanoparticles (NPs) in terms of biotechnological applications due to their enhanced properties.
They have a growing interest as promising biomedical agents for drug delivery, antibacterial,
and anticancer treatments due to their significant permeability and retention effects. Both of
nano-size copper (Cu) and selenium (Se) exhibited a significant activity in biological
treatment and drug delivery systems. Consequently, the present work aimed to focus on the
novel biogenic synthesis of Cu-Se BNPs using cell-free extract of a marine bacterium, and
studying their anticancer and antioxidant activities. Based on 16S rDNA sequencing, the
isolated marine bacterium was identified Bacillus amyloliquefaciens by phylogenetic analysis.
Biogenic synthesis of Cu-Se BNPs was optimized by studying the effect of some physiological
factors such as reaction time, pH, and temperature. Based on the reaction conditions, the
biologically synthesized Cu-Se NPs was obtained with different particle size that ranged from
15.7-106.0 nm. The spherical small sized (15.7 nm) bimetallic Cu-Se BNPs displayed
anticancer activity against HepG2 and MDA cell lines, while the cell viability was reduced by
87 % and 81 %, respectively. The estimated IC50 values were 696.4 µg/ ml for HepG2 and
273.9 µg/ ml for MDA, while scavenging capacity (SC) of Cu-Se BNPs (SC50 = 305.3 µM)
showed lower ability to 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) scavenging compared
to ascorbic acid (SC50 = 95.9 µM). |
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| ISSN: | 2537-0286 2537-0294 |