TDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord

TDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord

Abstract Neuronal and glial cytoplasmic inclusions positive for TAR DNA-binding protein 43 (TDP-43) are the defining pathological hallmark of 97% of amyotrophic lateral sclerosis (ALS) and 50% of frontotemporal dementia (FTD). The ALS-FTD clinicopathological spectrum variably involves cortical and s...

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Bibliographic Details
Main Authors: Emily Feneberg, Alexander G. Thompson, Philip D. Charles, Iolanda Vendrell, Benedikt M. Kessler, Roman Fischer, Olaf Ansorge, Elizabeth Gray, Kevin Talbot, Martin R. Turner
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Acta Neuropathologica Communications
Subjects:
TDP-43
Amyotrophic lateral sclerosis
Proteomics
Tissue
Brain
Spinal cord
Online Access:https://doi.org/10.1186/s40478-025-02084-y
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