Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end

Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end

Abstract Albumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation. However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-li...

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Main Authors: Jeannette Nilsen, Kristin Hovden Aaen, Sopisa Benjakul, Fulgencio Ruso-Julve, Thomas Uwe Greiner, Daniela Bejan, Maria Stensland, Sachin Singh, Tilman Schlothauer, Inger Sandlie, Jan Terje Andersen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08249-8
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