Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid dis...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/629637 |
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| _version_ | 1832552393345073152 |
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| author | Robin L. Marcus Odessa Addison Leland E. Dibble K. Bo Foreman Glen Morrell Paul LaStayo |
| author_facet | Robin L. Marcus Odessa Addison Leland E. Dibble K. Bo Foreman Glen Morrell Paul LaStayo |
| author_sort | Robin L. Marcus |
| collection | DOAJ |
| description | Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results. The predictors as a group contributed 27–45% of the variance in all outcome measures; however, IMAT contributed between 8–15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions. Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community. |
| format | Article |
| id | doaj-art-d22d309a9f544a9b8388a9ed03d3de62 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-d22d309a9f544a9b8388a9ed03d3de622025-02-03T05:58:45ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/629637629637Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older IndividualsRobin L. Marcus0Odessa Addison1Leland E. Dibble2K. Bo Foreman3Glen Morrell4Paul LaStayo5Department of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake, UT 84108, USADepartment of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake, UT 84108, USADepartment of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake, UT 84108, USADepartment of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake, UT 84108, USADepartment of Radiology, University of Utah, 30 N 1900 E, Salt Lake, UT 84132, USADepartment of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake, UT 84108, USAObjective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results. The predictors as a group contributed 27–45% of the variance in all outcome measures; however, IMAT contributed between 8–15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions. Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community.http://dx.doi.org/10.1155/2012/629637 |
| spellingShingle | Robin L. Marcus Odessa Addison Leland E. Dibble K. Bo Foreman Glen Morrell Paul LaStayo Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals Journal of Aging Research |
| title | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
| title_full | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
| title_fullStr | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
| title_full_unstemmed | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
| title_short | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
| title_sort | intramuscular adipose tissue sarcopenia and mobility function in older individuals |
| url | http://dx.doi.org/10.1155/2012/629637 |
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