The interface of depression and diabetes: treatment considerations
Abstract This state-of-the-art review explores the relationship between depression and diabetes, highlighting the two-way influences that make treatment challenging and worsen the outcomes of both conditions. Depression and diabetes often co-occur and share genetic, lifestyle, and psychosocial risk...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-025-03234-5 |
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| _version_ | 1832585386106290176 |
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| author | Giuseppe Fanelli Emanuel Raschi Gaye Hafez Silke Matura Carmen Schiweck Elisabetta Poluzzi Carlotta Lunghi |
| author_facet | Giuseppe Fanelli Emanuel Raschi Gaye Hafez Silke Matura Carmen Schiweck Elisabetta Poluzzi Carlotta Lunghi |
| author_sort | Giuseppe Fanelli |
| collection | DOAJ |
| description | Abstract This state-of-the-art review explores the relationship between depression and diabetes, highlighting the two-way influences that make treatment challenging and worsen the outcomes of both conditions. Depression and diabetes often co-occur and share genetic, lifestyle, and psychosocial risk factors. Lifestyle elements such as diet, physical activity, and sleep patterns play a role on the development and management of both conditions, highlighting the need for integrated treatment strategies. The evidence suggests that traditional management strategies focusing on either condition in isolation fall short of addressing the intertwined nature of diabetes and depression. Instead, integrated care models encompassing psychological support and medical management are recommended to improve treatment efficacy and patient adherence. Such models require collaboration across multiple healthcare disciplines, including endocrinology, psychiatry, and primary care, to offer a holistic approach to patient care. This review also identifies significant patient-related barriers to effective management, such as stigma, psychological resistance, and health literacy, which need to be addressed through patient-centered education and support systems. Future directions for research include longitudinal studies in diverse populations to further elucidate causal relationships and the exploration of novel therapeutic targets, as well as the effectiveness of healthcare models aimed at preventing the onset of one condition in individuals diagnosed with the other. |
| format | Article |
| id | doaj-art-d22d10cb67c3493ea9e58fb0c3cc9fd5 |
| institution | Kabale University |
| issn | 2158-3188 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj-art-d22d10cb67c3493ea9e58fb0c3cc9fd52025-01-26T12:53:42ZengNature Publishing GroupTranslational Psychiatry2158-31882025-01-0115111510.1038/s41398-025-03234-5The interface of depression and diabetes: treatment considerationsGiuseppe Fanelli0Emanuel Raschi1Gaye Hafez2Silke Matura3Carmen Schiweck4Elisabetta Poluzzi5Carlotta Lunghi6Department of Biomedical and Neuromotor Sciences, University of BolognaDepartment of Medical and Surgical Sciences, University of BolognaDepartment of Pharmacology, Faculty of Pharmacy, Altinbas UniversityInstitute of General Practice, Goethe University FrankfurtDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University FrankfurtDepartment of Medical and Surgical Sciences, University of BolognaDepartment of Medical and Surgical Sciences, University of BolognaAbstract This state-of-the-art review explores the relationship between depression and diabetes, highlighting the two-way influences that make treatment challenging and worsen the outcomes of both conditions. Depression and diabetes often co-occur and share genetic, lifestyle, and psychosocial risk factors. Lifestyle elements such as diet, physical activity, and sleep patterns play a role on the development and management of both conditions, highlighting the need for integrated treatment strategies. The evidence suggests that traditional management strategies focusing on either condition in isolation fall short of addressing the intertwined nature of diabetes and depression. Instead, integrated care models encompassing psychological support and medical management are recommended to improve treatment efficacy and patient adherence. Such models require collaboration across multiple healthcare disciplines, including endocrinology, psychiatry, and primary care, to offer a holistic approach to patient care. This review also identifies significant patient-related barriers to effective management, such as stigma, psychological resistance, and health literacy, which need to be addressed through patient-centered education and support systems. Future directions for research include longitudinal studies in diverse populations to further elucidate causal relationships and the exploration of novel therapeutic targets, as well as the effectiveness of healthcare models aimed at preventing the onset of one condition in individuals diagnosed with the other.https://doi.org/10.1038/s41398-025-03234-5 |
| spellingShingle | Giuseppe Fanelli Emanuel Raschi Gaye Hafez Silke Matura Carmen Schiweck Elisabetta Poluzzi Carlotta Lunghi The interface of depression and diabetes: treatment considerations Translational Psychiatry |
| title | The interface of depression and diabetes: treatment considerations |
| title_full | The interface of depression and diabetes: treatment considerations |
| title_fullStr | The interface of depression and diabetes: treatment considerations |
| title_full_unstemmed | The interface of depression and diabetes: treatment considerations |
| title_short | The interface of depression and diabetes: treatment considerations |
| title_sort | interface of depression and diabetes treatment considerations |
| url | https://doi.org/10.1038/s41398-025-03234-5 |
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