Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review
This review article provides a comprehensive examination of liver injury patterns, specifically focusing on hepatocellular and cholestatic patterns, and their respective diagnostic approaches. It highlights the importance of differentiating between these patterns through detailed clinical evaluation...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2025-04-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| Subjects: | |
| Online Access: | https://ina-jghe.com/index.php/jghe/article/view/1020 |
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| _version_ | 1849309924418387968 |
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| author | Syifa Mustika Camoya Gersom Pradermchai Kongkam |
| author_facet | Syifa Mustika Camoya Gersom Pradermchai Kongkam |
| author_sort | Syifa Mustika |
| collection | DOAJ |
| description | This review article provides a comprehensive examination of liver injury patterns, specifically focusing on hepatocellular and cholestatic patterns, and their respective diagnostic approaches. It highlights the importance of differentiating between these patterns through detailed clinical evaluations and the use of specific liver enzymes, including aminotransferases, bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, 5'-nucleotidase, and lactate dehydrogenase. The review further explores liver function tests, such as albumin and prothrombin time, which are crucial in assessing liver function and guiding clinical management. A wide range of liver diseases is discussed, with a focus on those exhibiting hepatocellular patterns, such as viral hepatitis, acute liver failure, fatty liver disease (both alcoholic and non-alcoholic), and drug-induced liver injury (DILI), as well as other conditions like ischemic and autoimmune hepatitis. Cholestatic illnesses such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), bile duct blockages, and genetic cholestatic syndromes are also investigated. This study seeks to improve physicians' and researchers' awareness of liver diseases, serve as a valuable resource for future research and teaching, and contribute to the improvement of diagnostic and therapeutic techniques in hepatology.
Keywords : Cholestatic, hepatocellular, liver enzymes, liver functions |
| format | Article |
| id | doaj-art-d22ab037a57541fa83c4d6ea0ea40f9d |
| institution | Kabale University |
| issn | 1411-4801 2302-8181 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj-art-d22ab037a57541fa83c4d6ea0ea40f9d2025-08-20T03:53:56ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812025-04-01261596710.24871/261202559-67918Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature ReviewSyifa Mustika0Camoya Gersom1Pradermchai Kongkam2Gastroenterohepatology Division, Departement of Internal Medicine, RSUD Dr. Saiful Anwar, MalangDepartment of Internal Medicine, RSUD Dr. Saiful Anwar, MalangDivision of Hospital and Ambulatory Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandThis review article provides a comprehensive examination of liver injury patterns, specifically focusing on hepatocellular and cholestatic patterns, and their respective diagnostic approaches. It highlights the importance of differentiating between these patterns through detailed clinical evaluations and the use of specific liver enzymes, including aminotransferases, bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, 5'-nucleotidase, and lactate dehydrogenase. The review further explores liver function tests, such as albumin and prothrombin time, which are crucial in assessing liver function and guiding clinical management. A wide range of liver diseases is discussed, with a focus on those exhibiting hepatocellular patterns, such as viral hepatitis, acute liver failure, fatty liver disease (both alcoholic and non-alcoholic), and drug-induced liver injury (DILI), as well as other conditions like ischemic and autoimmune hepatitis. Cholestatic illnesses such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), bile duct blockages, and genetic cholestatic syndromes are also investigated. This study seeks to improve physicians' and researchers' awareness of liver diseases, serve as a valuable resource for future research and teaching, and contribute to the improvement of diagnostic and therapeutic techniques in hepatology. Keywords : Cholestatic, hepatocellular, liver enzymes, liver functionshttps://ina-jghe.com/index.php/jghe/article/view/1020cholestatic, hepatocellular, liver enzymes, liver functions |
| spellingShingle | Syifa Mustika Camoya Gersom Pradermchai Kongkam Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy cholestatic, hepatocellular, liver enzymes, liver functions |
| title | Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review |
| title_full | Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review |
| title_fullStr | Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review |
| title_full_unstemmed | Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review |
| title_short | Approach to Patients with Increased Liver Biochemical and Function Tests : A Literature Review |
| title_sort | approach to patients with increased liver biochemical and function tests a literature review |
| topic | cholestatic, hepatocellular, liver enzymes, liver functions |
| url | https://ina-jghe.com/index.php/jghe/article/view/1020 |
| work_keys_str_mv | AT syifamustika approachtopatientswithincreasedliverbiochemicalandfunctiontestsaliteraturereview AT camoyagersom approachtopatientswithincreasedliverbiochemicalandfunctiontestsaliteraturereview AT pradermchaikongkam approachtopatientswithincreasedliverbiochemicalandfunctiontestsaliteraturereview |