Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS
Objective: Rheumatoid arthritis (RA) is an inflammatory, autoimmune systemic disease. This study aimed to compare the demographic, clinical characteristics, treatment choices, and treatment responses of seronegative (SN) and seropositive (SP) RA patients who were receiving or newly started biologica...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Turkish Society for Rheumatology
2025-03-01
|
| Series: | Ulusal Romatoloji Dergisi |
| Subjects: | |
| Online Access: | https://www.raeddergisi.org/articles/comparison-of-seropositive-and-seronegative-rheumatoid-arthritis-patients-using-or-about-to-be-initiated-with-biological-dmards/doi/raed.galenos.2025.22043 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850095688624373760 |
|---|---|
| author | Zehra Özsoy Şerife Asya Germe Gizem Ayan Güllü Sandal Uzun Mustafa Ekici Erdinç Ünaldı Levent Kılıç Ali Akdoğan Şule Apras Bilgen Sedat Kiraz Ali İhsan Ertenli |
| author_facet | Zehra Özsoy Şerife Asya Germe Gizem Ayan Güllü Sandal Uzun Mustafa Ekici Erdinç Ünaldı Levent Kılıç Ali Akdoğan Şule Apras Bilgen Sedat Kiraz Ali İhsan Ertenli |
| author_sort | Zehra Özsoy |
| collection | DOAJ |
| description | Objective: Rheumatoid arthritis (RA) is an inflammatory, autoimmune systemic disease. This study aimed to compare the demographic, clinical characteristics, treatment choices, and treatment responses of seronegative (SN) and seropositive (SP) RA patients who were receiving or newly started biological treatment.
Methods: The files and records of patients registered with Hacettepe University Biological Database with RA diagnosis who were planned to use biological disease-modifying antirheumatic drugs (b-DMARDs) between 2010-2024 were scanned. RA patients were divided into two groups as SPRA and SNRA. Demographic characteristics, disease duration, bDMARD use follow-up period, comorbidities, RA extra-articular findings, visual analog scale (VAS) global, VAS pain, VAS fatigue, Health Assessment Questionnaire-Disability index were recorded for RA patients included in the study.
Results: Two thousand five hundred and fifty-nine patients were included in the study. Median age of the patients was 55 years and 2034 of them were female. 75% of the patients were SPRA, 25% were SNRA. Although the DAS-28 score did not create a statistically significant difference when compared between the two groups, the rate of patients with low disease activity was higher in the seronegative group, while the rate of patients with moderate and high disease activity was higher in the SPRA group. When patients were evaluated according to the disease activity score (DAS-28) disease activity score after b-DMARD treatment, the proportion of patients who achieved remission or low disease activity was higher in the seronegative group. Among extra-articular findings, the frequency of interstitial lung disease and sicca symptoms were higher in the SPRA group.
Conclusion: SPRA and SNRA can be considered as two separate subtypes of RA with differences in clinical features, extra-articular involvement findings, disease activities, treatment choices and treatment responses. |
| format | Article |
| id | doaj-art-d229d9593abe4645882ab655a763dccd |
| institution | DOAJ |
| issn | 2651-2653 2651-2661 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Turkish Society for Rheumatology |
| record_format | Article |
| series | Ulusal Romatoloji Dergisi |
| spelling | doaj-art-d229d9593abe4645882ab655a763dccd2025-08-20T02:41:23ZengTurkish Society for RheumatologyUlusal Romatoloji Dergisi2651-26532651-26612025-03-01171535910.4274/raed.galenos.2025.22043Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDSZehra Özsoy0https://orcid.org/0000-0002-4534-4929Şerife Asya Germe1https://orcid.org/0009-0001-4068-9899Gizem Ayan2https://orcid.org/0000-0003-1889-9619Güllü Sandal Uzun3https://orcid.org/0000-0002-5010-9114Mustafa Ekici4https://orcid.org/0000-0002-8757-6226Erdinç Ünaldı5https://orcid.org/0009-0005-4381-202XLevent Kılıç6https://orcid.org/0000-0003-1064-9690Ali Akdoğan7https://orcid.org/0000-0001-6895-9144Şule Apras Bilgen8https://orcid.org/0000-0001-8208-1585Sedat Kiraz9https://orcid.org/0000-0003-2802-6061Ali İhsan Ertenli10https://orcid.org/0000-0002-3904-0769Hacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeHacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, TürkiyeObjective: Rheumatoid arthritis (RA) is an inflammatory, autoimmune systemic disease. This study aimed to compare the demographic, clinical characteristics, treatment choices, and treatment responses of seronegative (SN) and seropositive (SP) RA patients who were receiving or newly started biological treatment. Methods: The files and records of patients registered with Hacettepe University Biological Database with RA diagnosis who were planned to use biological disease-modifying antirheumatic drugs (b-DMARDs) between 2010-2024 were scanned. RA patients were divided into two groups as SPRA and SNRA. Demographic characteristics, disease duration, bDMARD use follow-up period, comorbidities, RA extra-articular findings, visual analog scale (VAS) global, VAS pain, VAS fatigue, Health Assessment Questionnaire-Disability index were recorded for RA patients included in the study. Results: Two thousand five hundred and fifty-nine patients were included in the study. Median age of the patients was 55 years and 2034 of them were female. 75% of the patients were SPRA, 25% were SNRA. Although the DAS-28 score did not create a statistically significant difference when compared between the two groups, the rate of patients with low disease activity was higher in the seronegative group, while the rate of patients with moderate and high disease activity was higher in the SPRA group. When patients were evaluated according to the disease activity score (DAS-28) disease activity score after b-DMARD treatment, the proportion of patients who achieved remission or low disease activity was higher in the seronegative group. Among extra-articular findings, the frequency of interstitial lung disease and sicca symptoms were higher in the SPRA group. Conclusion: SPRA and SNRA can be considered as two separate subtypes of RA with differences in clinical features, extra-articular involvement findings, disease activities, treatment choices and treatment responses.https://www.raeddergisi.org/articles/comparison-of-seropositive-and-seronegative-rheumatoid-arthritis-patients-using-or-about-to-be-initiated-with-biological-dmards/doi/raed.galenos.2025.22043rheumatoid arthritisseropositiveseronegativeb-dmard |
| spellingShingle | Zehra Özsoy Şerife Asya Germe Gizem Ayan Güllü Sandal Uzun Mustafa Ekici Erdinç Ünaldı Levent Kılıç Ali Akdoğan Şule Apras Bilgen Sedat Kiraz Ali İhsan Ertenli Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS Ulusal Romatoloji Dergisi rheumatoid arthritis seropositive seronegative b-dmard |
| title | Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS |
| title_full | Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS |
| title_fullStr | Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS |
| title_full_unstemmed | Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS |
| title_short | Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS |
| title_sort | comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological dmards |
| topic | rheumatoid arthritis seropositive seronegative b-dmard |
| url | https://www.raeddergisi.org/articles/comparison-of-seropositive-and-seronegative-rheumatoid-arthritis-patients-using-or-about-to-be-initiated-with-biological-dmards/doi/raed.galenos.2025.22043 |
| work_keys_str_mv | AT zehraozsoy comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT serifeasyagerme comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT gizemayan comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT gullusandaluzun comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT mustafaekici comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT erdincunaldı comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT leventkılıc comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT aliakdogan comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT suleaprasbilgen comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT sedatkiraz comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards AT aliihsanertenli comparisonofseropositiveandseronegativerheumatoidarthritispatientsusingorabouttobeinitiatedwithbiologicaldmards |