Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China
Background. Immunoglobulin E (IgE) is the most important promoter of allergic inflammation. However, there are few systematic studies on IgE in age range, genders, disease spectrum, and time regularity. Aim. To screen the common allergens, allergen spectrum, and IgE difference between type 2 inflamm...
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/6627087 |
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| author | Zhang Xu-De Guo Bei-Bei Wang Xi-Juan Li Hai-Bo Zhang Li-Li Liu Feng-Xia |
| author_facet | Zhang Xu-De Guo Bei-Bei Wang Xi-Juan Li Hai-Bo Zhang Li-Li Liu Feng-Xia |
| author_sort | Zhang Xu-De |
| collection | DOAJ |
| description | Background. Immunoglobulin E (IgE) is the most important promoter of allergic inflammation. However, there are few systematic studies on IgE in age range, genders, disease spectrum, and time regularity. Aim. To screen the common allergens, allergen spectrum, and IgE difference between type 2 inflammatory allergic diseases and other allergic diseases in Weifang, China. Methods. A retrospective study was performed by estimating patients’ clinical data suffering from allergic diseases (urticaria, pollinosis, allergic rhinitis, atopic dermatitis, and bronchial asthma) between May 2019 and April 2020 using an allergen detection kit of Macro-Union Pharmaceutical. Results. 732 of the 1367 patients showed different antigen positive, and the positive rate was 53.5%. The most common allergens were dust mites, mixed fungi, Artemisia pollen, cat/dog dander, and cockroaches. There were 27.0% (369/1367) of the patients with single positive allergen-specific IgE (sIgE), 26.5% (363/1367) with multiple-positive IgE. The total immunoglobulin E (tIgE) levels varied with gender, age, and type of disease. There was a difference in the distribution of allergens between children and adults. A positive correlation between the serum-specific IgE and the corresponding local inhaled allergen density was observed. Conclusions. In this study, we found that type 2 inflammatory allergic diseases have higher serum IgE and a higher probability of inhaled sIgE positive. According to age, gender, and condition, serological IgE detection of allergens provides new insight into the early diagnosis and prevention of allergic diseases. |
| format | Article |
| id | doaj-art-d229c57fad3a4a1db63e465f504e317c |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d229c57fad3a4a1db63e465f504e317c2025-08-20T02:19:44ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/66270876627087Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, ChinaZhang Xu-De0Guo Bei-Bei1Wang Xi-Juan2Li Hai-Bo3Zhang Li-Li4Liu Feng-Xia5Department of Allergy, The First Affiliated Hospital of Weifang Medical University/Weifang People’s Hospital, Weifang, ChinaDepartment of Allergy, The First Affiliated Hospital of Weifang Medical University/Weifang People’s Hospital, Weifang, ChinaDepartment of Allergy, The First Affiliated Hospital of Weifang Medical University/Weifang People’s Hospital, Weifang, ChinaDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University/Weifang People’s Hospital, Weifang, ChinaDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University/Weifang People’s Hospital, Weifang, ChinaDepartment of Allergy, The First Affiliated Hospital of Weifang Medical University/Weifang People’s Hospital, Weifang, ChinaBackground. Immunoglobulin E (IgE) is the most important promoter of allergic inflammation. However, there are few systematic studies on IgE in age range, genders, disease spectrum, and time regularity. Aim. To screen the common allergens, allergen spectrum, and IgE difference between type 2 inflammatory allergic diseases and other allergic diseases in Weifang, China. Methods. A retrospective study was performed by estimating patients’ clinical data suffering from allergic diseases (urticaria, pollinosis, allergic rhinitis, atopic dermatitis, and bronchial asthma) between May 2019 and April 2020 using an allergen detection kit of Macro-Union Pharmaceutical. Results. 732 of the 1367 patients showed different antigen positive, and the positive rate was 53.5%. The most common allergens were dust mites, mixed fungi, Artemisia pollen, cat/dog dander, and cockroaches. There were 27.0% (369/1367) of the patients with single positive allergen-specific IgE (sIgE), 26.5% (363/1367) with multiple-positive IgE. The total immunoglobulin E (tIgE) levels varied with gender, age, and type of disease. There was a difference in the distribution of allergens between children and adults. A positive correlation between the serum-specific IgE and the corresponding local inhaled allergen density was observed. Conclusions. In this study, we found that type 2 inflammatory allergic diseases have higher serum IgE and a higher probability of inhaled sIgE positive. According to age, gender, and condition, serological IgE detection of allergens provides new insight into the early diagnosis and prevention of allergic diseases.http://dx.doi.org/10.1155/2021/6627087 |
| spellingShingle | Zhang Xu-De Guo Bei-Bei Wang Xi-Juan Li Hai-Bo Zhang Li-Li Liu Feng-Xia Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China Mediators of Inflammation |
| title | Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China |
| title_full | Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China |
| title_fullStr | Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China |
| title_full_unstemmed | Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China |
| title_short | Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China |
| title_sort | serum ige predicts difference of population and allergens in allergic diseases data from weifang city china |
| url | http://dx.doi.org/10.1155/2021/6627087 |
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