The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease
Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/142468 |
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| author | Farshad Kajbaf Romuald Mentaverri Momar Diouf Albert Fournier Said Kamel Jean-Daniel Lalau |
| author_facet | Farshad Kajbaf Romuald Mentaverri Momar Diouf Albert Fournier Said Kamel Jean-Daniel Lalau |
| author_sort | Farshad Kajbaf |
| collection | DOAJ |
| description | Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studied in patients categorized according to the severity of CKD and their vitamin D status. A multivariate linear regression model was used to determine whether 25(OH)D and HbA1c levels were independently associated after adjustment for a number of covariates (including erythrocyte metformin levels). Results. We identified 542 reports from 245 patients. The mean HbA1c value was 6.7±1.0% in vitamin D sufficiency, 7.3±1.5% in insufficiency, and 8.4±2.0% in deficiency (P<0.0001). There was a negative correlation between 25(OH)D and HbA1c levels for the population as a whole (r=-0.387, P<0.0001) and in the CKD severity subgroups (r=-0.384, P<0.0001 and r=-0.333, P<0.0001 for CKD stages 1–3 and 4-5, resp.). In the multivariate analysis, the 25(OH)D level was the only factor associated with HbA1c (P<0.0001). Conclusion. 25(OH)D levels were negatively correlated with HbA1c levels independently of study covariates. |
| format | Article |
| id | doaj-art-d2249cfa4af442938c2e755603038083 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d2249cfa4af442938c2e7556030380832025-02-03T01:00:04ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/142468142468The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney DiseaseFarshad Kajbaf0Romuald Mentaverri1Momar Diouf2Albert Fournier3Said Kamel4Jean-Daniel Lalau5Department of Endocrinology and Nutrition, University Hospital of Amiens, 80054 Amiens, FranceINSERM Unit 1088, Jules Verne University of Picardie, 80037 Amiens, FranceClinical Research Center, University Hospital of Amiens, 80054 Amiens, FranceDepartment of Clinical Nephrology, University Hospital of Amiens, 80054 Amiens, FranceBone Biology and Endocrine Division, University Hospital of Amiens, 80054 Amiens, FranceDepartment of Endocrinology and Nutrition, University Hospital of Amiens, 80054 Amiens, FranceAim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studied in patients categorized according to the severity of CKD and their vitamin D status. A multivariate linear regression model was used to determine whether 25(OH)D and HbA1c levels were independently associated after adjustment for a number of covariates (including erythrocyte metformin levels). Results. We identified 542 reports from 245 patients. The mean HbA1c value was 6.7±1.0% in vitamin D sufficiency, 7.3±1.5% in insufficiency, and 8.4±2.0% in deficiency (P<0.0001). There was a negative correlation between 25(OH)D and HbA1c levels for the population as a whole (r=-0.387, P<0.0001) and in the CKD severity subgroups (r=-0.384, P<0.0001 and r=-0.333, P<0.0001 for CKD stages 1–3 and 4-5, resp.). In the multivariate analysis, the 25(OH)D level was the only factor associated with HbA1c (P<0.0001). Conclusion. 25(OH)D levels were negatively correlated with HbA1c levels independently of study covariates.http://dx.doi.org/10.1155/2014/142468 |
| spellingShingle | Farshad Kajbaf Romuald Mentaverri Momar Diouf Albert Fournier Said Kamel Jean-Daniel Lalau The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease International Journal of Endocrinology |
| title | The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease |
| title_full | The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease |
| title_fullStr | The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease |
| title_full_unstemmed | The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease |
| title_short | The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease |
| title_sort | association between 25 hydroxyvitamin d and hemoglobin a1c levels in patients with type 2 diabetes and stage 1 5 chronic kidney disease |
| url | http://dx.doi.org/10.1155/2014/142468 |
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