The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study
Aim: To compare the clinical improvement of two-regimen treatment using esomeprazole alone vs quadruple therapy in non-ulcer Helicobacter Pylori (H. pylori) gastritis in Vietnamese’s children. Methods: A prospective study, carried out in 52 children, 5 to 11 years old, receive a quadruple therapy...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2025-01-01
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| Series: | Revista Cubana de Medicina Militar |
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| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/71256 |
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| author | Hien Thi Phan Ngoan Thi Dao Phuong Minh Nguyen Phu Huy Nguyen Ha Thu Nguyen Linh Thi Thuy Nguyen |
| author_facet | Hien Thi Phan Ngoan Thi Dao Phuong Minh Nguyen Phu Huy Nguyen Ha Thu Nguyen Linh Thi Thuy Nguyen |
| author_sort | Hien Thi Phan |
| collection | DOAJ |
| description |
Aim: To compare the clinical improvement of two-regimen treatment using esomeprazole alone vs quadruple therapy in non-ulcer Helicobacter Pylori (H. pylori) gastritis in Vietnamese’s children.
Methods: A prospective study, carried out in 52 children, 5 to 11 years old, receive a quadruple therapy including 2 mg/kg/day esomeprazole, bismuth 8 mg/kg/day, amoxicillin 100 mg/kg/day and metronidazole 25 mg/kg/day for the first two weeks, then 2 mg/kg/day esomeprazole for the other two weeks.
Results: Asymptomatic children after one month of treatment stopping were found in 34 children (58.6%). H. pylori eradication rate in intention to treat and per-protocol analysis showed a 31/55 (56.4%) and 31/52 (59.6%) patients after four weeks of treatment stopping.
Conclusion: Quadruple regimen even with high dose of esomeprazole and amoxicillin combined metronidazole and bismuth showed a lower eradication rate and did not achieve the usual recommended rate > 90%.
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| format | Article |
| id | doaj-art-d21fadbed74a4e36aedfa813f9b3b62a |
| institution | Kabale University |
| issn | 1561-3046 |
| language | Spanish |
| publishDate | 2025-01-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista Cubana de Medicina Militar |
| spelling | doaj-art-d21fadbed74a4e36aedfa813f9b3b62a2025-01-14T19:00:02ZspaECIMEDRevista Cubana de Medicina Militar1561-30462025-01-01541The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective studyHien Thi Phan0https://orcid.org/0000-0002-0235-9135Ngoan Thi Dao1https://orcid.org/0009-0006-8565-9155Phuong Minh Nguyen2https://orcid.org/0000-0003-0948-6871Phu Huy Nguyen3https://orcid.org/0000-0001-6731-618XHa Thu Nguyen4https://orcid.org/0000-0003-1248-6071Linh Thi Thuy Nguyen5https://orcid.org/0009-0007-1718-2938Vinmec Times City International Hospital, 458 Minh Khai Street, Times City urban area, Hai Ba Trung district, Hanoi City, VietnamVinmec Times City International Hospital, 458 Minh Khai Street, Times City urban area, Hai Ba Trung district, Hanoi city, VietnamVietnam Military Medical University, 160 Phung Hung road, Ha Dong district, Hanoi city, VietnamVietnam National Children’s Hospital, 18/879 La Thanh street, Hanoi city, VietnamNational Institute of Occupational and Environmental Health, Hai Ba Trung district, Hanoi city, VietnamVinmec Times City International Hospital, 458 Minh Khai Street, Times City urban area, Hai Ba Trung district, Hanoi city, Vietnam Aim: To compare the clinical improvement of two-regimen treatment using esomeprazole alone vs quadruple therapy in non-ulcer Helicobacter Pylori (H. pylori) gastritis in Vietnamese’s children. Methods: A prospective study, carried out in 52 children, 5 to 11 years old, receive a quadruple therapy including 2 mg/kg/day esomeprazole, bismuth 8 mg/kg/day, amoxicillin 100 mg/kg/day and metronidazole 25 mg/kg/day for the first two weeks, then 2 mg/kg/day esomeprazole for the other two weeks. Results: Asymptomatic children after one month of treatment stopping were found in 34 children (58.6%). H. pylori eradication rate in intention to treat and per-protocol analysis showed a 31/55 (56.4%) and 31/52 (59.6%) patients after four weeks of treatment stopping. Conclusion: Quadruple regimen even with high dose of esomeprazole and amoxicillin combined metronidazole and bismuth showed a lower eradication rate and did not achieve the usual recommended rate > 90%. https://revmedmilitar.sld.cu/index.php/mil/article/view/71256childrenesomeprazolegastritisHelicobacter pyloriquadruple therapy |
| spellingShingle | Hien Thi Phan Ngoan Thi Dao Phuong Minh Nguyen Phu Huy Nguyen Ha Thu Nguyen Linh Thi Thuy Nguyen The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study Revista Cubana de Medicina Militar children esomeprazole gastritis Helicobacter pylori quadruple therapy |
| title | The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study |
| title_full | The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study |
| title_fullStr | The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study |
| title_full_unstemmed | The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study |
| title_short | The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study |
| title_sort | efficacy of quadruple therapy in non ulcer helicobacter pylory gastritis in children a prospective study |
| topic | children esomeprazole gastritis Helicobacter pylori quadruple therapy |
| url | https://revmedmilitar.sld.cu/index.php/mil/article/view/71256 |
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