The efficacy of quadruple therapy in non-ulcer Helicobacter Pylory gastritis in children: A prospective study
Aim: To compare the clinical improvement of two-regimen treatment using esomeprazole alone vs quadruple therapy in non-ulcer Helicobacter Pylori (H. pylori) gastritis in Vietnamese’s children. Methods: A prospective study, carried out in 52 children, 5 to 11 years old, receive a quadruple therapy...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
ECIMED
2025-01-01
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| Series: | Revista Cubana de Medicina Militar |
| Subjects: | |
| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/71256 |
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| Summary: | Aim: To compare the clinical improvement of two-regimen treatment using esomeprazole alone vs quadruple therapy in non-ulcer Helicobacter Pylori (H. pylori) gastritis in Vietnamese’s children.
Methods: A prospective study, carried out in 52 children, 5 to 11 years old, receive a quadruple therapy including 2 mg/kg/day esomeprazole, bismuth 8 mg/kg/day, amoxicillin 100 mg/kg/day and metronidazole 25 mg/kg/day for the first two weeks, then 2 mg/kg/day esomeprazole for the other two weeks.
Results: Asymptomatic children after one month of treatment stopping were found in 34 children (58.6%). H. pylori eradication rate in intention to treat and per-protocol analysis showed a 31/55 (56.4%) and 31/52 (59.6%) patients after four weeks of treatment stopping.
Conclusion: Quadruple regimen even with high dose of esomeprazole and amoxicillin combined metronidazole and bismuth showed a lower eradication rate and did not achieve the usual recommended rate > 90%.
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| ISSN: | 1561-3046 |