Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients
Objective To study the relationship between left ventricular hypertrophy（LVH）and Vitamin D [25（OH）D<sub>3</sub>] in maintenance dialysis patients.Methods The clinical and laboratory results of 80 patients with maintenance dialysis were retrospectively analyzed.Meanwhile,Vitamin D levels...
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Editorial Department of Journal of Clinical Nephrology
2020-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | ZOU Yuan-fang DENG Hui-zhao LIANG Xiang LUO Wan-ying |
| author_facet | ZOU Yuan-fang DENG Hui-zhao LIANG Xiang LUO Wan-ying |
| author_sort | ZOU Yuan-fang |
| collection | DOAJ |
| description | Objective To study the relationship between left ventricular hypertrophy（LVH）and Vitamin D [25（OH）D<sub>3</sub>] in maintenance dialysis patients.Methods The clinical and laboratory results of 80 patients with maintenance dialysis were retrospectively analyzed.Meanwhile,Vitamin D levels were detected with radioimmunoassay.The relationships between serum Vitamin D levels and some laboratory parameters were analyzed by using Pearson correlation analysis.The risk factors of left ventricular hypertrophy were investigated through Logistic regression analysis.ROC curve was used to analyze 25（OH）D<sub>3</sub> and predict the optimal cutoff value of LVH.Results Serum 25（OH）D<sub>3</sub> levels of 80 patients with maintenance hemodialysis were（15.2±3.6）ng/mL.The 25（OH）D<sub>3</sub> levels of the patients in the LVH group were significantly lower than those in the non-LVH group[（13.5±2.8）vs（17.8±3.2）ng/mL,P<0.05].The 25（OH）D<sub>3</sub> levels exhibited negative correlation with left ventricular end diastolic diameter（LVDd）,left ventricular posterior wall thickness（LVPWT）,interventricular septum thickness（IVST）and left ventricular mass index（LVMI）,and positive correlation with left ventricular ejection fraction（LVEF）（r=-0.582,P=0.032;r=-0.562,P=0.038;r=-0.498,P=0.046;r=-0.641,P=0.024;r=0.726,P=0.018）.Multivariable logistic regression analysis showed that low 25（OH）D<sub>3</sub>,C-reaction protein（CRP）,total cholesterol（TC）,hypertension,anemia were independent risk factors for LVH;ROC curve analysis showed the area under the curve that baseline serum Vitamin D deficiency was used to predict an area under the curve of 0.842,with the optimal cutoff value of 14.28 ng/mL,sensitivity of 68.8% and specificity of 81.2%.Conclusions The 25（OH）D<sub>3</sub> levels of patients with maintenance hemodialysis decrease significantly,and vitamin D deficiency is an independent factor of LVH in MHD patients.Vitamin D deficiency may be involved in pathogenesis and progression of cardiovascular diseases in hemodialysis patients. |
| format | Article |
| id | doaj-art-d21be25fbd8947aaae48472941260b7d |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2020-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-d21be25fbd8947aaae48472941260b7d2025-08-20T02:16:14ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902020-01-012046546957906815Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patientsZOU Yuan-fangDENG Hui-zhaoLIANG XiangLUO Wan-yingObjective To study the relationship between left ventricular hypertrophy（LVH）and Vitamin D [25（OH）D<sub>3</sub>] in maintenance dialysis patients.Methods The clinical and laboratory results of 80 patients with maintenance dialysis were retrospectively analyzed.Meanwhile,Vitamin D levels were detected with radioimmunoassay.The relationships between serum Vitamin D levels and some laboratory parameters were analyzed by using Pearson correlation analysis.The risk factors of left ventricular hypertrophy were investigated through Logistic regression analysis.ROC curve was used to analyze 25（OH）D<sub>3</sub> and predict the optimal cutoff value of LVH.Results Serum 25（OH）D<sub>3</sub> levels of 80 patients with maintenance hemodialysis were（15.2±3.6）ng/mL.The 25（OH）D<sub>3</sub> levels of the patients in the LVH group were significantly lower than those in the non-LVH group[（13.5±2.8）vs（17.8±3.2）ng/mL,P<0.05].The 25（OH）D<sub>3</sub> levels exhibited negative correlation with left ventricular end diastolic diameter（LVDd）,left ventricular posterior wall thickness（LVPWT）,interventricular septum thickness（IVST）and left ventricular mass index（LVMI）,and positive correlation with left ventricular ejection fraction（LVEF）（r=-0.582,P=0.032;r=-0.562,P=0.038;r=-0.498,P=0.046;r=-0.641,P=0.024;r=0.726,P=0.018）.Multivariable logistic regression analysis showed that low 25（OH）D<sub>3</sub>,C-reaction protein（CRP）,total cholesterol（TC）,hypertension,anemia were independent risk factors for LVH;ROC curve analysis showed the area under the curve that baseline serum Vitamin D deficiency was used to predict an area under the curve of 0.842,with the optimal cutoff value of 14.28 ng/mL,sensitivity of 68.8% and specificity of 81.2%.Conclusions The 25（OH）D<sub>3</sub> levels of patients with maintenance hemodialysis decrease significantly,and vitamin D deficiency is an independent factor of LVH in MHD patients.Vitamin D deficiency may be involved in pathogenesis and progression of cardiovascular diseases in hemodialysis patients.http://www.lcszb.com/thesisDetails?columnId=57906815&Fpath=home&index=0Maintenance dialysisVitamin D deficiencyLeft ventricular hypertrophy |
| spellingShingle | ZOU Yuan-fang DENG Hui-zhao LIANG Xiang LUO Wan-ying Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients Linchuang shenzangbing zazhi Maintenance dialysis Vitamin D deficiency Left ventricular hypertrophy |
| title | Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients |
| title_full | Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients |
| title_fullStr | Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients |
| title_full_unstemmed | Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients |
| title_short | Correlation of Vitamin D with left ventricular hypertrophy in maintenance hemodialysis patients |
| title_sort | correlation of vitamin d with left ventricular hypertrophy in maintenance hemodialysis patients |
| topic | Maintenance dialysis Vitamin D deficiency Left ventricular hypertrophy |
| url | http://www.lcszb.com/thesisDetails?columnId=57906815&Fpath=home&index=0 |
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