Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia

Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia

Abstract Background Acute hyperglycemia on admission is frequently observed during the early phase after acute myocardial infarction (MI), even without the history of diabetes mellitus. We previously reported that inhibiting Na+/H+ exchanger 1 (NHE1) activity post-MI may improve outcomes, but not in...

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Main Authors: Kai Jiang, Fanghua Su, Ruhua Deng, Yue Xu, Anqi Qin, Xun Yuan, Dongmei Xing, Yang Chen, Dandan Wang, Lan Shen, John Hwa, Lei Hou, Yaozu Xiang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cardiovascular Diabetology
Online Access:https://doi.org/10.1186/s12933-025-02743-3
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