DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN
Aim: to investigate sFas-receptor and its ligand, sFas-L, cytochrome C and annexin V as the apoptotic markers in children with CKD to determine the renal cell apoptosis role in the progression of a renal disease. Patients and methods: 68 children with CKD 1–3 from 3 to 17 years were examined. Result...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2013-09-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/290 |
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| author | O. V. Komarova A. G. Kucherenko I. E. Smirnov A. N. Tsygin |
| author_facet | O. V. Komarova A. G. Kucherenko I. E. Smirnov A. N. Tsygin |
| author_sort | O. V. Komarova |
| collection | DOAJ |
| description | Aim: to investigate sFas-receptor and its ligand, sFas-L, cytochrome C and annexin V as the apoptotic markers in children with CKD to determine the renal cell apoptosis role in the progression of a renal disease. Patients and methods: 68 children with CKD 1–3 from 3 to 17 years were examined. Results: sFas-R, sFas-L, annexin V significant differed from normal value at all stages of CKD. Cytochrome C level was significantly higher than normal in children with CKD1. But tended to increase at and 2 and 3 stages correspondingly. Significant correlation was determinated between proteinuria and the combination of all four markers. Сomparing serum levels of apoptosis markers in children with non-immune disorders without renal dysfunction treated and iACE not treated and in patients with CKD-2 t a significant excess of the level of sFas-R in patients without iACE therapy was found. Conclusions: Fas-mediated and mitochondrial programmed cell death are implicated in development and progression of CKD. ACE inhibitors reduced the severity of apoptosis, primarily by inhibiting the activity of its Fas-mediated pathway. |
| format | Article |
| id | doaj-art-d21788017f0c4e3d9eb7009b8916e896 |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2013-09-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-d21788017f0c4e3d9eb7009b8916e8962025-08-20T03:35:16Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352013-09-0112510410710.15690/vsp.v12i5.807290DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDRENO. V. Komarova0A. G. Kucherenko1I. E. Smirnov2A. N. Tsygin3Scientific Centre of Children Health of RAMS, MoscowScientific Centre of Children Health of RAMS, MoscowScientific Centre of Children Health of RAMS, MoscowScientific Centre of Children Health of RAMS, MoscowAim: to investigate sFas-receptor and its ligand, sFas-L, cytochrome C and annexin V as the apoptotic markers in children with CKD to determine the renal cell apoptosis role in the progression of a renal disease. Patients and methods: 68 children with CKD 1–3 from 3 to 17 years were examined. Results: sFas-R, sFas-L, annexin V significant differed from normal value at all stages of CKD. Cytochrome C level was significantly higher than normal in children with CKD1. But tended to increase at and 2 and 3 stages correspondingly. Significant correlation was determinated between proteinuria and the combination of all four markers. Сomparing serum levels of apoptosis markers in children with non-immune disorders without renal dysfunction treated and iACE not treated and in patients with CKD-2 t a significant excess of the level of sFas-R in patients without iACE therapy was found. Conclusions: Fas-mediated and mitochondrial programmed cell death are implicated in development and progression of CKD. ACE inhibitors reduced the severity of apoptosis, primarily by inhibiting the activity of its Fas-mediated pathway.https://vsp.spr-journal.ru/jour/article/view/290childrenchronic kidney diseaseapoptosisfas-induced |
| spellingShingle | O. V. Komarova A. G. Kucherenko I. E. Smirnov A. N. Tsygin DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN Вопросы современной педиатрии children chronic kidney disease apoptosis fas-induced |
| title | DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN |
| title_full | DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN |
| title_fullStr | DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN |
| title_full_unstemmed | DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN |
| title_short | DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN |
| title_sort | dynamics of concentration of apoptosis serum markers in assessment of prognosis of chronic kidney disease in children |
| topic | children chronic kidney disease apoptosis fas-induced |
| url | https://vsp.spr-journal.ru/jour/article/view/290 |
| work_keys_str_mv | AT ovkomarova dynamicsofconcentrationofapoptosisserummarkersinassessmentofprognosisofchronickidneydiseaseinchildren AT agkucherenko dynamicsofconcentrationofapoptosisserummarkersinassessmentofprognosisofchronickidneydiseaseinchildren AT iesmirnov dynamicsofconcentrationofapoptosisserummarkersinassessmentofprognosisofchronickidneydiseaseinchildren AT antsygin dynamicsofconcentrationofapoptosisserummarkersinassessmentofprognosisofchronickidneydiseaseinchildren |