The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysis
Background and Purpose: Spasticity is a disabling complication of spinal cord injury (SCI). The administration of various medications is not satisfactory. Studies show the effects of onabotulinumtoxinA treatment for spasticity in patients with SCI. We designed this study to systematically review the...
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Mazandaran University of Medical Sciences
2025-02-01
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| Series: | علوم بهداشتی ایران |
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| Online Access: | http://jhs.mazums.ac.ir/article-1-942-en.pdf |
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| author | Maryam Hosseini Saeed Vaheb Mohaddeseh Azadvari Mohsen Rastkar Mahsa Ghajarzadeh Maryam Cheraghali Seyede Zahra Emami Razavi |
| author_facet | Maryam Hosseini Saeed Vaheb Mohaddeseh Azadvari Mohsen Rastkar Mahsa Ghajarzadeh Maryam Cheraghali Seyede Zahra Emami Razavi |
| author_sort | Maryam Hosseini |
| collection | DOAJ |
| description | Background and Purpose: Spasticity is a disabling complication of spinal cord injury (SCI). The administration of various medications is not satisfactory. Studies show the effects of onabotulinumtoxinA treatment for spasticity in patients with SCI. We designed this study to systematically review the effects of onabotulinumtoxinA toxin on spasticity status in patients with SCI.
Materials and Methods: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and gray literature, including references and conference abstracts, were systematically searched by two researchers published before September 2023. Data regarding the total number of participants, first author, publication year, country of origin, mean age, follow-up time, the site of injection, main findings, and side effects were extracted and recorded.
Results: A literature search revealed 2914 articles. After deleting duplicates, 1688 remained. After careful evaluation of the full texts, six articles remained. Two studies reported improvement in the modified Ashworth scale after treatment, while one showed opposite results. Improvement of spasticity and spasticity-related pain was observed in one study, and a decrease in the modified Tardieu scale was found in another study. Improvement in upper-extremity function, positioning, and pain after treatment was shown in a study done in the USA.
Conclusion: The results of this systematic review show that administration of onabotulinumtoxinA toxin may improve spasticity in patients with SCI. |
| format | Article |
| id | doaj-art-d21491b39a4746d195be93e7b4e71587 |
| institution | DOAJ |
| issn | 2322-553X 2981-2240 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | علوم بهداشتی ایران |
| spelling | doaj-art-d21491b39a4746d195be93e7b4e715872025-08-20T02:53:30ZengMazandaran University of Medical Sciencesعلوم بهداشتی ایران2322-553X2981-22402025-02-011316574The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysisMaryam Hosseini0Saeed Vaheb1Mohaddeseh Azadvari2Mohsen Rastkar3Mahsa Ghajarzadeh4Maryam Cheraghali5Seyede Zahra Emami Razavi6 Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran. Background and Purpose: Spasticity is a disabling complication of spinal cord injury (SCI). The administration of various medications is not satisfactory. Studies show the effects of onabotulinumtoxinA treatment for spasticity in patients with SCI. We designed this study to systematically review the effects of onabotulinumtoxinA toxin on spasticity status in patients with SCI. Materials and Methods: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and gray literature, including references and conference abstracts, were systematically searched by two researchers published before September 2023. Data regarding the total number of participants, first author, publication year, country of origin, mean age, follow-up time, the site of injection, main findings, and side effects were extracted and recorded. Results: A literature search revealed 2914 articles. After deleting duplicates, 1688 remained. After careful evaluation of the full texts, six articles remained. Two studies reported improvement in the modified Ashworth scale after treatment, while one showed opposite results. Improvement of spasticity and spasticity-related pain was observed in one study, and a decrease in the modified Tardieu scale was found in another study. Improvement in upper-extremity function, positioning, and pain after treatment was shown in a study done in the USA. Conclusion: The results of this systematic review show that administration of onabotulinumtoxinA toxin may improve spasticity in patients with SCI.http://jhs.mazums.ac.ir/article-1-942-en.pdfspinal cord injury (sci)spasticitybotulinum toxinstype a |
| spellingShingle | Maryam Hosseini Saeed Vaheb Mohaddeseh Azadvari Mohsen Rastkar Mahsa Ghajarzadeh Maryam Cheraghali Seyede Zahra Emami Razavi The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysis علوم بهداشتی ایران spinal cord injury (sci) spasticity botulinum toxins type a |
| title | The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_full | The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_fullStr | The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_full_unstemmed | The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_short | The Effects of OnabotulinumtoxinA Treatment for Spasticity in Patients With Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_sort | effects of onabotulinumtoxina treatment for spasticity in patients with spinal cord injury a systematic review and meta analysis |
| topic | spinal cord injury (sci) spasticity botulinum toxins type a |
| url | http://jhs.mazums.ac.ir/article-1-942-en.pdf |
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