Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors
Alzheimer’s disease (AD) is a neurodegenerative disorder with a strong genetic component. This research aims to identify the relationship between ABCA7 rs3764650, PSEN1 rs165932, and AD in the northeast Algerian population and investigate genetic risk factors contributing to disease susceptibility....
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2025-01-01
|
| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0354-4664/2025/0354-46642500005A.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850272120246894592 |
|---|---|
| author | Achou Rayene Ayachi Ouarda Sariyah Boukhenaf Yasmina Laouar Rania Gharzouli Razika Mzahem Abderrahim Boulala Houda Abadi Noureddine Satta Dalila |
| author_facet | Achou Rayene Ayachi Ouarda Sariyah Boukhenaf Yasmina Laouar Rania Gharzouli Razika Mzahem Abderrahim Boulala Houda Abadi Noureddine Satta Dalila |
| author_sort | Achou Rayene |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a neurodegenerative disorder with a strong genetic component. This research aims to identify the relationship between ABCA7 rs3764650, PSEN1 rs165932, and AD in the northeast Algerian population and investigate genetic risk factors contributing to disease susceptibility. A case-control study was performed with 98 patients and 156 controls. DNA was isolated from blood samples by salting out. Genotyping of ABCA7 and PSEN1 polymorphisms was conducted using PCR-RFLP. Significant associations were observed between ABCA7 rs3764650 and AD under dominant and additive models. Similarly, PSEN1 rs165932 was associated with a higher risk of AD under dominant, recessive, and additive models. The frequency of the ABCA7 G allele was significantly associated with PSEN1 T allele carriers (P=0.033), with no significant association observed in non-carriers. In contrast, the PSEN1 T allele frequency was significant in both ABCA7 G allele carriers (P=0.006) and non-carriers (P=0.001). Allelic frequencies for ABCA7 and PSEN1 were higher in late-onset cases (P=0.003; P< 0.001) and females (P=0.006; P< 0.001). This study highlights the association of the ABCA7 rs3764650 G and PSEN1 rs165932 T alleles with AD susceptibility, particularly in females and late-onset cases, suggesting their relevance as genetic markers of disease risk. |
| format | Article |
| id | doaj-art-d2111d94a832406697f2775d09cd3efc |
| institution | OA Journals |
| issn | 0354-4664 1821-4339 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj-art-d2111d94a832406697f2775d09cd3efc2025-08-20T01:51:57ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392025-01-01771496010.2298/ABS250208005A0354-46642500005AGenetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factorsAchou Rayene0https://orcid.org/0009-0004-0709-0130Ayachi Ouarda Sariyah1https://orcid.org/0000-0003-4522-3219Boukhenaf Yasmina2https://orcid.org/0009-0003-5159-5921Laouar Rania3https://orcid.org/0000-0002-4392-5156Gharzouli Razika4https://orcid.org/0009-0007-0008-5410Mzahem Abderrahim5https://orcid.org/0000-0001-6378-9422Boulala Houda6https://orcid.org/0009-0008-3387-0949Abadi Noureddine7https://orcid.org/0000-0002-0861-8951Satta Dalila8https://orcid.org/0000-0002-5090-9859Laboratory of Molecular and Cellular Biology, Department of Animal Biology, Frères Mentouri Constantine University, Constantine, AlgeriaPathology, Health and Biotechnology Division, National Research Center of Biotechnology (CRBt), Constantine, AlgeriaLaboratory of Molecular and Cellular Biology, Department of Animal Biology, Frères Mentouri Constantine University, Constantine, AlgeriaLaboratory of Molecular and Cellular Biology, Department of Animal Biology, Frères Mentouri Constantine University, Constantine, AlgeriaLaboratory of Molecular and Cellular Biology, Department of Animal Biology, Frères Mentouri Constantine University, Constantine, AlgeriaDepartment of Neurology, Salah Boubnider Constantine University, Constantine, AlgeriaDepartment of Neurology, Salah Boubnider Constantine University, Constantine, AlgeriaLaboratory of Biology and Molecular Genetics, Salah Boubnider Constantine University, Constantine, AlgeriaLaboratory of Molecular and Cellular Biology, Department of Animal Biology, Frères Mentouri Constantine University, Constantine, AlgeriaAlzheimer’s disease (AD) is a neurodegenerative disorder with a strong genetic component. This research aims to identify the relationship between ABCA7 rs3764650, PSEN1 rs165932, and AD in the northeast Algerian population and investigate genetic risk factors contributing to disease susceptibility. A case-control study was performed with 98 patients and 156 controls. DNA was isolated from blood samples by salting out. Genotyping of ABCA7 and PSEN1 polymorphisms was conducted using PCR-RFLP. Significant associations were observed between ABCA7 rs3764650 and AD under dominant and additive models. Similarly, PSEN1 rs165932 was associated with a higher risk of AD under dominant, recessive, and additive models. The frequency of the ABCA7 G allele was significantly associated with PSEN1 T allele carriers (P=0.033), with no significant association observed in non-carriers. In contrast, the PSEN1 T allele frequency was significant in both ABCA7 G allele carriers (P=0.006) and non-carriers (P=0.001). Allelic frequencies for ABCA7 and PSEN1 were higher in late-onset cases (P=0.003; P< 0.001) and females (P=0.006; P< 0.001). This study highlights the association of the ABCA7 rs3764650 G and PSEN1 rs165932 T alleles with AD susceptibility, particularly in females and late-onset cases, suggesting their relevance as genetic markers of disease risk.https://doiserbia.nb.rs/img/doi/0354-4664/2025/0354-46642500005A.pdfalzheimer’s diseasepolymorphismsabca7psen1northeast algerian population |
| spellingShingle | Achou Rayene Ayachi Ouarda Sariyah Boukhenaf Yasmina Laouar Rania Gharzouli Razika Mzahem Abderrahim Boulala Houda Abadi Noureddine Satta Dalila Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors Archives of Biological Sciences alzheimer’s disease polymorphisms abca7 psen1 northeast algerian population |
| title | Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors |
| title_full | Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors |
| title_fullStr | Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors |
| title_full_unstemmed | Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors |
| title_short | Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors |
| title_sort | genetic association of abca7 and psen1 polymorphisms with alzheimer s disease in the northeast algerian population exploring risk factors |
| topic | alzheimer’s disease polymorphisms abca7 psen1 northeast algerian population |
| url | https://doiserbia.nb.rs/img/doi/0354-4664/2025/0354-46642500005A.pdf |
| work_keys_str_mv | AT achourayene geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT ayachiouardasariyah geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT boukhenafyasmina geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT laouarrania geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT gharzoulirazika geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT mzahemabderrahim geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT boulalahouda geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT abadinoureddine geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors AT sattadalila geneticassociationofabca7andpsen1polymorphismswithalzheimersdiseaseinthenortheastalgerianpopulationexploringriskfactors |