The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation
We aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation. The first part records the large range of liver deficiency models that can be developed in Nude mice: surgical partial hepatectomy, acut...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/140147 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850174107845394432 |
|---|---|
| author | Isabelle Vidal Lysiane Richert |
| author_facet | Isabelle Vidal Lysiane Richert |
| author_sort | Isabelle Vidal |
| collection | DOAJ |
| description | We aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation. The first part records the large range of liver deficiency models that can be developed in Nude mice: surgical partial hepatectomy, acute toxic liver deficiency, chronic cirrhosis, and transgenic liver injury. The second part tackles the outcome of rat hepatocyte as well as human cell transplantation, both mature hepatocyte and hepatic progenitor, into Nude mouse submitted to liver injury. Results are discussed and compared to other available immunodeficient mouse models. The issue of humanized liver creation is also addressed. Altogether, these results show that Nude mouse appears to be a suitable small animal model to expand our insight into liver cell engraftment and regeneration. |
| format | Article |
| id | doaj-art-d20c57b949eb4b0b984e95b673298e1a |
| institution | OA Journals |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-d20c57b949eb4b0b984e95b673298e1a2025-08-20T02:19:42ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/140147140147The Nude Mouse as Model for Liver Deficiency Study and Treatment and XenotransplantationIsabelle Vidal0Lysiane Richert1Faculté de Médecine et de Pharmacie, EA 3921, IFR 133, 25030 Besançon, FranceFaculté de Médecine et de Pharmacie, EA 3921, IFR 133, 25030 Besançon, FranceWe aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation. The first part records the large range of liver deficiency models that can be developed in Nude mice: surgical partial hepatectomy, acute toxic liver deficiency, chronic cirrhosis, and transgenic liver injury. The second part tackles the outcome of rat hepatocyte as well as human cell transplantation, both mature hepatocyte and hepatic progenitor, into Nude mouse submitted to liver injury. Results are discussed and compared to other available immunodeficient mouse models. The issue of humanized liver creation is also addressed. Altogether, these results show that Nude mouse appears to be a suitable small animal model to expand our insight into liver cell engraftment and regeneration.http://dx.doi.org/10.1155/2012/140147 |
| spellingShingle | Isabelle Vidal Lysiane Richert The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation International Journal of Hepatology |
| title | The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation |
| title_full | The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation |
| title_fullStr | The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation |
| title_full_unstemmed | The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation |
| title_short | The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation |
| title_sort | nude mouse as model for liver deficiency study and treatment and xenotransplantation |
| url | http://dx.doi.org/10.1155/2012/140147 |
| work_keys_str_mv | AT isabellevidal thenudemouseasmodelforliverdeficiencystudyandtreatmentandxenotransplantation AT lysianerichert thenudemouseasmodelforliverdeficiencystudyandtreatmentandxenotransplantation AT isabellevidal nudemouseasmodelforliverdeficiencystudyandtreatmentandxenotransplantation AT lysianerichert nudemouseasmodelforliverdeficiencystudyandtreatmentandxenotransplantation |