Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis.
Chikungunya virus is transmitted by mosquitoes and causes severe, debilitating infectious arthritis in humans. The need for an animal model to study the disease process and evaluate potential treatments is imminent as the virus continues its spread into novel geographic locations. Golden hamsters (M...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0130150 |
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| author | Angela M Bosco-Lauth Sushan Han Airn Hartwig Richard A Bowen |
| author_facet | Angela M Bosco-Lauth Sushan Han Airn Hartwig Richard A Bowen |
| author_sort | Angela M Bosco-Lauth |
| collection | DOAJ |
| description | Chikungunya virus is transmitted by mosquitoes and causes severe, debilitating infectious arthritis in humans. The need for an animal model to study the disease process and evaluate potential treatments is imminent as the virus continues its spread into novel geographic locations. Golden hamsters (Mesocricetus auratus) are often used as outbred laboratory animal models for arboviral diseases. Here we demonstrate that hamsters inoculated with chikungunya virus developed viremia and histopathologic lesions in their limbs and joints similar to those seen in human patients. The virus disseminated rapidly and was found in every major organ, including brain, within a few days of infection. Hamsters did not manifest overt clinical signs, and the virus was generally cleared within 4 days, followed by a strong neutralizing antibody response. These results indicate that hamsters are highly susceptible to chikungunya virus infection and develop myositis and tenosynovitis similar to human patients followed by a complete recovery. This animal model may be useful for testing antiviral drugs and vaccines. |
| format | Article |
| id | doaj-art-d205e84862624fcdaafe0060a23cab83 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d205e84862624fcdaafe0060a23cab832025-08-20T03:46:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013015010.1371/journal.pone.0130150Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis.Angela M Bosco-LauthSushan HanAirn HartwigRichard A BowenChikungunya virus is transmitted by mosquitoes and causes severe, debilitating infectious arthritis in humans. The need for an animal model to study the disease process and evaluate potential treatments is imminent as the virus continues its spread into novel geographic locations. Golden hamsters (Mesocricetus auratus) are often used as outbred laboratory animal models for arboviral diseases. Here we demonstrate that hamsters inoculated with chikungunya virus developed viremia and histopathologic lesions in their limbs and joints similar to those seen in human patients. The virus disseminated rapidly and was found in every major organ, including brain, within a few days of infection. Hamsters did not manifest overt clinical signs, and the virus was generally cleared within 4 days, followed by a strong neutralizing antibody response. These results indicate that hamsters are highly susceptible to chikungunya virus infection and develop myositis and tenosynovitis similar to human patients followed by a complete recovery. This animal model may be useful for testing antiviral drugs and vaccines.https://doi.org/10.1371/journal.pone.0130150 |
| spellingShingle | Angela M Bosco-Lauth Sushan Han Airn Hartwig Richard A Bowen Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis. PLoS ONE |
| title | Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis. |
| title_full | Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis. |
| title_fullStr | Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis. |
| title_full_unstemmed | Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis. |
| title_short | Development of a Hamster Model for Chikungunya Virus Infection and Pathogenesis. |
| title_sort | development of a hamster model for chikungunya virus infection and pathogenesis |
| url | https://doi.org/10.1371/journal.pone.0130150 |
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