Systematic evaluation of immune regulation and modulation
Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in the field. Moreover, the identification and assessment of both predictive and prognostic bi...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2017-08-01
|
| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/5/1/21.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849720622545895424 |
|---|---|
| author | Francesco Marincola David F Stroncek Barbara Seliger Lisa H. Butterfield David R. Kaufman Firouzeh Korangy Sergio Rutella Peter P. Lee Madhav V. Dhodapkar Michael A. Cannarile Tim F. Greten Jean Charles Grivel Heidi H. Kong Janet C. Siebert Giorgio Trinchieri |
| author_facet | Francesco Marincola David F Stroncek Barbara Seliger Lisa H. Butterfield David R. Kaufman Firouzeh Korangy Sergio Rutella Peter P. Lee Madhav V. Dhodapkar Michael A. Cannarile Tim F. Greten Jean Charles Grivel Heidi H. Kong Janet C. Siebert Giorgio Trinchieri |
| author_sort | Francesco Marincola |
| collection | DOAJ |
| description | Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in the field. Moreover, the identification and assessment of both predictive and prognostic biomarkers has become a key component to advancing these therapies. Thus, it is critical to develop systematic approaches to monitor the immune response and to interpret the data obtained from these assays. In order to address these issues and make recommendations to the field, the Society for Immunotherapy of Cancer reconvened the Immune Biomarkers Task Force. As a part of this Task Force, Working Group 3 (WG3) consisting of multidisciplinary experts from industry, academia, and government focused on the systematic assessment of immune regulation and modulation. In this review, the tumor microenvironment, microbiome, bone marrow, and adoptively transferred T cells will be used as examples to discuss the type and timing of sample collection. In addition, potential types of measurements, assays, and analyses will be discussed for each sample. Specifically, these recommendations will focus on the unique collection and assay requirements for the analysis of various samples as well as the high-throughput assays to evaluate potential biomarkers. |
| format | Article |
| id | doaj-art-d20229de7f9d4e8bb6ce0554b309b8d4 |
| institution | DOAJ |
| issn | 2051-1426 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-d20229de7f9d4e8bb6ce0554b309b8d42025-08-20T03:11:52ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262017-08-015110.1186/s40425-017-0223-8Systematic evaluation of immune regulation and modulationFrancesco Marincola0David F Stroncek1Barbara Seliger2Lisa H. Butterfield3David R. Kaufman4Firouzeh Korangy5Sergio Rutella6Peter P. Lee7Madhav V. Dhodapkar8Michael A. Cannarile9Tim F. Greten10Jean Charles Grivel11Heidi H. Kong12Janet C. Siebert13Giorgio Trinchieri14Aff6 0000 0004 0397 4222grid.467063.0Division of Translational MedicineSidra Medical and Research Center PO Box 26999 Al Luqta Street Doha QatarAff1 0000 0001 2297 5165grid.94365.3dDepartment of Transfusion MedicineNational Institutes of Health 10 Center Drive, Building 10, Room 3C720 20892 Bethesda MD USAAff13 0000 0001 0679 2801grid.9018.0Institute of Medical ImmunologyMartin Luther University Halle-Wittenberg Magdeburger Str. 2 Halle GermanyAff1 grid.412689.00000000106507433University of Pittsburgh Cancer InstituteUPMC Cancer Pavilion 5150 Centre Avenue (555) 15232 Pittsburgh PA USAAff7 0000 0001 2260 0793grid.417993.1Merck Research Laboratories PO Box 1000 UG 3CD28 19454 North Wales PA USAAff5 0000 0004 0483 9129grid.417768.bGI-Malignancy Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Building 10 Room 12 N226, 9000 Rockville 20892 Bethesda MD USA3Nottingham Trent University, Nottingham, East Midlands, UKAff9 0000 0004 0421 8357grid.410425.6Department of Immuno-Oncology, City of Hope 1500 East Duarte Road 91010 Duarte CA USAAff44 grid.47100.320000000419368710Department of Hematology & ImmunobiologyYale University Box 208021 333 Cedar Street 06510 New Haven CT USAAff3 Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich Nonnenwald 2 82377 Penzberg GermanyAff5 0000 0004 0483 9129grid.417768.bGI-Malignancy Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Building 10 Room 12 N226, 9000 Rockville 20892 Bethesda MD USAAff6 0000 0004 0397 4222grid.467063.0Division of Translational MedicineSidra Medical and Research Center PO Box 26999 Al Luqta Street Doha QatarAff8 0000 0004 1936 8075grid.48336.3aDermatology Branch, Center for Cancer ResearchNational Cancer Institute, National Institutes of Health Building 10, MSC 1908 20892-1908 Bethesda MD USAAff11 CytoAnalytics 3500 South Albion Street 80113 Cherry Hills Village CO USALaboratory of Integrative Cancer Immunology, National Cancer Institute Center for Cancer Research, Bethesda, Maryland, USACancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in the field. Moreover, the identification and assessment of both predictive and prognostic biomarkers has become a key component to advancing these therapies. Thus, it is critical to develop systematic approaches to monitor the immune response and to interpret the data obtained from these assays. In order to address these issues and make recommendations to the field, the Society for Immunotherapy of Cancer reconvened the Immune Biomarkers Task Force. As a part of this Task Force, Working Group 3 (WG3) consisting of multidisciplinary experts from industry, academia, and government focused on the systematic assessment of immune regulation and modulation. In this review, the tumor microenvironment, microbiome, bone marrow, and adoptively transferred T cells will be used as examples to discuss the type and timing of sample collection. In addition, potential types of measurements, assays, and analyses will be discussed for each sample. Specifically, these recommendations will focus on the unique collection and assay requirements for the analysis of various samples as well as the high-throughput assays to evaluate potential biomarkers.https://jitc.bmj.com/content/5/1/21.full |
| spellingShingle | Francesco Marincola David F Stroncek Barbara Seliger Lisa H. Butterfield David R. Kaufman Firouzeh Korangy Sergio Rutella Peter P. Lee Madhav V. Dhodapkar Michael A. Cannarile Tim F. Greten Jean Charles Grivel Heidi H. Kong Janet C. Siebert Giorgio Trinchieri Systematic evaluation of immune regulation and modulation Journal for ImmunoTherapy of Cancer |
| title | Systematic evaluation of immune regulation and modulation |
| title_full | Systematic evaluation of immune regulation and modulation |
| title_fullStr | Systematic evaluation of immune regulation and modulation |
| title_full_unstemmed | Systematic evaluation of immune regulation and modulation |
| title_short | Systematic evaluation of immune regulation and modulation |
| title_sort | systematic evaluation of immune regulation and modulation |
| url | https://jitc.bmj.com/content/5/1/21.full |
| work_keys_str_mv | AT francescomarincola systematicevaluationofimmuneregulationandmodulation AT davidfstroncek systematicevaluationofimmuneregulationandmodulation AT barbaraseliger systematicevaluationofimmuneregulationandmodulation AT lisahbutterfield systematicevaluationofimmuneregulationandmodulation AT davidrkaufman systematicevaluationofimmuneregulationandmodulation AT firouzehkorangy systematicevaluationofimmuneregulationandmodulation AT sergiorutella systematicevaluationofimmuneregulationandmodulation AT peterplee systematicevaluationofimmuneregulationandmodulation AT madhavvdhodapkar systematicevaluationofimmuneregulationandmodulation AT michaelacannarile systematicevaluationofimmuneregulationandmodulation AT timfgreten systematicevaluationofimmuneregulationandmodulation AT jeancharlesgrivel systematicevaluationofimmuneregulationandmodulation AT heidihkong systematicevaluationofimmuneregulationandmodulation AT janetcsiebert systematicevaluationofimmuneregulationandmodulation AT giorgiotrinchieri systematicevaluationofimmuneregulationandmodulation |