Neurosyphilis: A rare cause of encephalitis in a young male
Acute neurosyphilis is a rare but easily treatable cause of subacute confusion. Its clinical presentation is varied, with reported phenotypes ranging from acute stroke-like presentations to psychosis, dementia and meningoencephalitis. Neurosyphilis is easily detectable and treatable, despite its cli...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Clinical Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1470211825000302 |
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| author | William Cunningham Michael Keogh Nirmalan Arulanantham |
| author_facet | William Cunningham Michael Keogh Nirmalan Arulanantham |
| author_sort | William Cunningham |
| collection | DOAJ |
| description | Acute neurosyphilis is a rare but easily treatable cause of subacute confusion. Its clinical presentation is varied, with reported phenotypes ranging from acute stroke-like presentations to psychosis, dementia and meningoencephalitis. Neurosyphilis is easily detectable and treatable, despite its clinical heterogeneity. We present a 45-year-old man without HIV presenting with a subacute encephalitis, with cerebrospinal fluid and blood markers strongly positive for syphilis, with clinical improvement following 2 weeks of empirical intravenous antibiotic therapy. |
| format | Article |
| id | doaj-art-d1fe598317164341b6dc29a62819438a |
| institution | DOAJ |
| issn | 1470-2118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Medicine |
| spelling | doaj-art-d1fe598317164341b6dc29a62819438a2025-08-20T03:19:56ZengElsevierClinical Medicine1470-21182025-05-0125310031210.1016/j.clinme.2025.100312Neurosyphilis: A rare cause of encephalitis in a young maleWilliam Cunningham0Michael Keogh1Nirmalan Arulanantham2Queen Elizabeth University Hospital, North Cumbria Integrated Care NHS Trust, Acute Medicine, NHS Greater Glasgow and Clyde, Glasgow, United KingdomNewcastle Hospitals NHS Foundation Trust, Department of Neurology, Newcastle Upon Tyne, United KingdomNorth Cumbria Integrated Care NHS Trust, Department of Clinical Pharmacology and General Medicine, Carlisle CA2 7HY, United Kingdom; Corresponding author.Acute neurosyphilis is a rare but easily treatable cause of subacute confusion. Its clinical presentation is varied, with reported phenotypes ranging from acute stroke-like presentations to psychosis, dementia and meningoencephalitis. Neurosyphilis is easily detectable and treatable, despite its clinical heterogeneity. We present a 45-year-old man without HIV presenting with a subacute encephalitis, with cerebrospinal fluid and blood markers strongly positive for syphilis, with clinical improvement following 2 weeks of empirical intravenous antibiotic therapy.http://www.sciencedirect.com/science/article/pii/S1470211825000302NeurosyphilsSyphilisEncephalitisAutoimune encephalitis |
| spellingShingle | William Cunningham Michael Keogh Nirmalan Arulanantham Neurosyphilis: A rare cause of encephalitis in a young male Clinical Medicine Neurosyphils Syphilis Encephalitis Autoimune encephalitis |
| title | Neurosyphilis: A rare cause of encephalitis in a young male |
| title_full | Neurosyphilis: A rare cause of encephalitis in a young male |
| title_fullStr | Neurosyphilis: A rare cause of encephalitis in a young male |
| title_full_unstemmed | Neurosyphilis: A rare cause of encephalitis in a young male |
| title_short | Neurosyphilis: A rare cause of encephalitis in a young male |
| title_sort | neurosyphilis a rare cause of encephalitis in a young male |
| topic | Neurosyphils Syphilis Encephalitis Autoimune encephalitis |
| url | http://www.sciencedirect.com/science/article/pii/S1470211825000302 |
| work_keys_str_mv | AT williamcunningham neurosyphilisararecauseofencephalitisinayoungmale AT michaelkeogh neurosyphilisararecauseofencephalitisinayoungmale AT nirmalanarulanantham neurosyphilisararecauseofencephalitisinayoungmale |