Inosine-5′-monophosphate interacts with the TAS1R3 subunit to enhance sweet taste detection

Inosine-5′-monophosphate interacts with the TAS1R3 subunit to enhance sweet taste detection

Umami and sweet taste detection is mediated by the activation of the TAS1R1/TAS1R3 and TAS1R2/TAS1R3 receptors, respectively. TAS1R2-Venus flytrap domain (VFT) constitutes the primary ligand-binding site for most of the sweeteners whereas TAS1R1-VFT contains the orthosteric binding site for umami co...

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Bibliographic Details
Main Authors: Christine Belloir, Lucie Moitrier, Adeline Karolkowski, Nicolas Poirier, Fabrice Neiers, Loïc Briand
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Food Chemistry: Molecular Sciences
Subjects:
G-protein-coupled receptor
Taste receptor
Sweetener
Umami
Ribonucleotide
Online Access:http://www.sciencedirect.com/science/article/pii/S2666566225000073
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