Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China
Hepatitis E virus (HEV) is an important cause of acute hepatitis, however, is highly neglected and largely underreported. This study aimed to describe the detailed epidemiology of hepatitis E (HE) through a 10-year surveillance. A community-based active hepatitis surveillance was conducted between N...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2373315 |
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| author | Xingcheng Huang Xiaoxiang Zheng Lin Chen Chunlan Zhuang Changlin Yang Xia Zang Yijun Wang Hanmin Jiang Xiaomeng Huang Qiang Yan Zimin Tang Yingying Su Zizheng Zheng Ting Wu Xuefeng Zhang Yue Huang Shoujie Huang Fengcai Zhu Jun Zhang Ningshao Xia |
| author_facet | Xingcheng Huang Xiaoxiang Zheng Lin Chen Chunlan Zhuang Changlin Yang Xia Zang Yijun Wang Hanmin Jiang Xiaomeng Huang Qiang Yan Zimin Tang Yingying Su Zizheng Zheng Ting Wu Xuefeng Zhang Yue Huang Shoujie Huang Fengcai Zhu Jun Zhang Ningshao Xia |
| author_sort | Xingcheng Huang |
| collection | DOAJ |
| description | Hepatitis E virus (HEV) is an important cause of acute hepatitis, however, is highly neglected and largely underreported. This study aimed to describe the detailed epidemiology of hepatitis E (HE) through a 10-year surveillance. A community-based active hepatitis surveillance was conducted between November 2007 and October 2017 in 11 townships of Dongtai City in China, involving 355,673 residents. Serum samples were obtained from patients presenting with hepatitis symptoms for more than 3 days. Serum alanine aminotransferase (ALT) levels greater than 2.5 times the upper limit of normal (ULN) were considered acute hepatitis. Samples were subsequently tested for IgG and IgM anti-HEV antibodies, HEV RNA, and hepatitis B surface antigen (HBsAg). The data indicated the incidence of HE fluctuated downward from 2007 to 2017, with an average annual age-standardized incidence of 17.50 per 100,000, exceeding the 10.26 per 100,000 in the National Notifiable Disease Report System (NNDRS). The incidence was notably higher among males (20.95 per 100,000) and individuals aged 50–69 years (37.47 per 100,000). Genotype 4 (HEV-4) was the predominantly circulating genotype during the study period. Furthermore, the study revealed the incidence of hepatitis with HEV and hepatitis B virus (HBV) co-infection was 4.99 per 100,000. The active surveillance system identified a higher incidence of HE compared to NNDRS, with a decreased prevalence over a 10-year period. While efforts are still needed to prevent HE in high-risk populations, including individuals with hepatitis B and the elderly. |
| format | Article |
| id | doaj-art-d1f316324be145d988080ccc01f7e1ea |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-d1f316324be145d988080ccc01f7e1ea2025-08-20T02:21:02ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2373315Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern ChinaXingcheng Huang0Xiaoxiang Zheng1Lin Chen2Chunlan Zhuang3Changlin Yang4Xia Zang5Yijun Wang6Hanmin Jiang7Xiaomeng Huang8Qiang Yan9Zimin Tang10Yingying Su11Zizheng Zheng12Ting Wu13Xuefeng Zhang14Yue Huang15Shoujie Huang16Fengcai Zhu17Jun Zhang18Ningshao Xia19State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaDongtai Center for Disease Control and Prevention, Dongtai, People’s Republic of ChinaDongtai Center for Disease Control and Prevention, Dongtai, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaDongtai Center for Disease Control and Prevention, Dongtai, People’s Republic of ChinaDongtai Center for Disease Control and Prevention, Dongtai, People’s Republic of ChinaDongtai Center for Disease Control and Prevention, Dongtai, People’s Republic of ChinaDongtai Center for Disease Control and Prevention, Dongtai, People’s Republic of ChinaDongtai Center for Disease Control and Prevention, Dongtai, People’s Republic of ChinaXiamen Innodx Biotech Company, Xiamen, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaJiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaJiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaHepatitis E virus (HEV) is an important cause of acute hepatitis, however, is highly neglected and largely underreported. This study aimed to describe the detailed epidemiology of hepatitis E (HE) through a 10-year surveillance. A community-based active hepatitis surveillance was conducted between November 2007 and October 2017 in 11 townships of Dongtai City in China, involving 355,673 residents. Serum samples were obtained from patients presenting with hepatitis symptoms for more than 3 days. Serum alanine aminotransferase (ALT) levels greater than 2.5 times the upper limit of normal (ULN) were considered acute hepatitis. Samples were subsequently tested for IgG and IgM anti-HEV antibodies, HEV RNA, and hepatitis B surface antigen (HBsAg). The data indicated the incidence of HE fluctuated downward from 2007 to 2017, with an average annual age-standardized incidence of 17.50 per 100,000, exceeding the 10.26 per 100,000 in the National Notifiable Disease Report System (NNDRS). The incidence was notably higher among males (20.95 per 100,000) and individuals aged 50–69 years (37.47 per 100,000). Genotype 4 (HEV-4) was the predominantly circulating genotype during the study period. Furthermore, the study revealed the incidence of hepatitis with HEV and hepatitis B virus (HBV) co-infection was 4.99 per 100,000. The active surveillance system identified a higher incidence of HE compared to NNDRS, with a decreased prevalence over a 10-year period. While efforts are still needed to prevent HE in high-risk populations, including individuals with hepatitis B and the elderly.https://www.tandfonline.com/doi/10.1080/22221751.2024.2373315Hepatitis Eepidemiologysurveillancedisease notificationhepatitis B |
| spellingShingle | Xingcheng Huang Xiaoxiang Zheng Lin Chen Chunlan Zhuang Changlin Yang Xia Zang Yijun Wang Hanmin Jiang Xiaomeng Huang Qiang Yan Zimin Tang Yingying Su Zizheng Zheng Ting Wu Xuefeng Zhang Yue Huang Shoujie Huang Fengcai Zhu Jun Zhang Ningshao Xia Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China Emerging Microbes and Infections Hepatitis E epidemiology surveillance disease notification hepatitis B |
| title | Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China |
| title_full | Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China |
| title_fullStr | Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China |
| title_full_unstemmed | Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China |
| title_short | Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China |
| title_sort | active surveillance of hepatitis e a 10 year epidemiological analysis in a city in eastern china |
| topic | Hepatitis E epidemiology surveillance disease notification hepatitis B |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2373315 |
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