GRLGRN: graph representation-based learning to infer gene regulatory networks from single-cell RNA-seq data

Abstract Background A gene regulatory network (GRN) is a graph-level representation that describes the regulatory relationships between transcription factors and target genes in cells. The reconstruction of GRNs can help investigate cellular dynamics, drug design, and metabolic systems, and the rapi...

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Bibliographic Details
Main Authors: Kai Wang, Yulong Li, Fei Liu, Xiaoli Luan, Xinglong Wang, Jingwen Zhou
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Bioinformatics
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Online Access:https://doi.org/10.1186/s12859-025-06116-1
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