Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases
Abstract Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Research in recent years has expanded our understanding of these aspects, highlighting their...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-025-03362-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850156499598311424 |
|---|---|
| author | Qingfu Zhang Jianyao Su Zhichao Li Su Han Chuanhe Wang Zhijun Sun |
| author_facet | Qingfu Zhang Jianyao Su Zhichao Li Su Han Chuanhe Wang Zhijun Sun |
| author_sort | Qingfu Zhang |
| collection | DOAJ |
| description | Abstract Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Research in recent years has expanded our understanding of these aspects, highlighting their significance in various physiological and pathological processes. Migrasomes have been found to play crucial roles in normal physiological functions, including embryonic development, vascular homeostasis, material transport, and mitochondrial quality control. Additionally, emerging evidence suggests their involvement in various diseases; however, clinical research on their roles remains limited. Current studies indicate that migrasomes may contribute to disease pathogenesis and hold potential for diagnostic and therapeutic applications. This review consolidates existing clinical research on migrasomes, focusing on their role in disease mechanisms and their use in medical applications. By examining their biological structure and function, this review aims to generate insights that encourage further research, ultimately contributing to advancements in disease prevention and treatment. Graphical abstract |
| format | Article |
| id | doaj-art-d1e6960129764fa3b355250b830c4063 |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-d1e6960129764fa3b355250b830c40632025-08-20T02:24:30ZengBMCJournal of Nanobiotechnology1477-31552025-04-0123112210.1186/s12951-025-03362-6Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseasesQingfu Zhang0Jianyao Su1Zhichao Li2Su Han3Chuanhe Wang4Zhijun Sun5Department of Cardiology, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, Shengjing Hospital of China Medical UniversityAbstract Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Research in recent years has expanded our understanding of these aspects, highlighting their significance in various physiological and pathological processes. Migrasomes have been found to play crucial roles in normal physiological functions, including embryonic development, vascular homeostasis, material transport, and mitochondrial quality control. Additionally, emerging evidence suggests their involvement in various diseases; however, clinical research on their roles remains limited. Current studies indicate that migrasomes may contribute to disease pathogenesis and hold potential for diagnostic and therapeutic applications. This review consolidates existing clinical research on migrasomes, focusing on their role in disease mechanisms and their use in medical applications. By examining their biological structure and function, this review aims to generate insights that encourage further research, ultimately contributing to advancements in disease prevention and treatment. Graphical abstracthttps://doi.org/10.1186/s12951-025-03362-6DiseaseCell communicationOrganellesTreatmentPathologyMigrasome |
| spellingShingle | Qingfu Zhang Jianyao Su Zhichao Li Su Han Chuanhe Wang Zhijun Sun Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases Journal of Nanobiotechnology Disease Cell communication Organelles Treatment Pathology Migrasome |
| title | Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases |
| title_full | Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases |
| title_fullStr | Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases |
| title_full_unstemmed | Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases |
| title_short | Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases |
| title_sort | migrasomes as intercellular messengers potential in the pathological mechanism diagnosis and treatment of clinical diseases |
| topic | Disease Cell communication Organelles Treatment Pathology Migrasome |
| url | https://doi.org/10.1186/s12951-025-03362-6 |
| work_keys_str_mv | AT qingfuzhang migrasomesasintercellularmessengerspotentialinthepathologicalmechanismdiagnosisandtreatmentofclinicaldiseases AT jianyaosu migrasomesasintercellularmessengerspotentialinthepathologicalmechanismdiagnosisandtreatmentofclinicaldiseases AT zhichaoli migrasomesasintercellularmessengerspotentialinthepathologicalmechanismdiagnosisandtreatmentofclinicaldiseases AT suhan migrasomesasintercellularmessengerspotentialinthepathologicalmechanismdiagnosisandtreatmentofclinicaldiseases AT chuanhewang migrasomesasintercellularmessengerspotentialinthepathologicalmechanismdiagnosisandtreatmentofclinicaldiseases AT zhijunsun migrasomesasintercellularmessengerspotentialinthepathologicalmechanismdiagnosisandtreatmentofclinicaldiseases |