Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms
Abstract Background Endovascular aneurysm repair (EVAR) is now considered the preferred treatment modality in most abdominal aortic aneurysm (AAA) patients. Objectives The objective of this study was to quantify and evaluate MMP-2, MMP-9, TIMP-1, and TIMP-2 expression response to EVAR based on ser...
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Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)
2025-05-01
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| Series: | Jornal Vascular Brasileiro |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492025000100312&lng=en&tlng=en |
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| author | Túlio Fabiano de Oliveira Leite Elpidio Ribeiro da Silva Karoline Gomes Daniela Pretti da Cunha Tirapelli Edwaldo Edner Joviliano |
| author_facet | Túlio Fabiano de Oliveira Leite Elpidio Ribeiro da Silva Karoline Gomes Daniela Pretti da Cunha Tirapelli Edwaldo Edner Joviliano |
| author_sort | Túlio Fabiano de Oliveira Leite |
| collection | DOAJ |
| description | Abstract Background Endovascular aneurysm repair (EVAR) is now considered the preferred treatment modality in most abdominal aortic aneurysm (AAA) patients. Objectives The objective of this study was to quantify and evaluate MMP-2, MMP-9, TIMP-1, and TIMP-2 expression response to EVAR based on serum assays at 6-month follow-up. Methods 47 patients with AAA who underwent EVAR and ten people with no comorbidities were recruited for the study. Plasma levels of MMPs and TIMPs were assayed by ELISA preoperatively and after 6 months in the group submitted to EVAR and only once in the control group. Demographic profiles, clinical follow-up data, and imaging exams with angiotomography performed preoperatively and after 6 months were collected. Results Forty-seven patients with AAA were treated with EVAR. 87.2% of these patients were male and 68.08% were smokers. There were no deaths in the first 30 days. Ten patients (21.27%) had an endoleak during the 6-month postoperative period. Higher MMP and TIMP levels were observed in the AAA patients compared with patients in the control group, although without statistical significance. After EVAR, there were increases in MMP and TIMP levels both in the group with endoleaks and in the group without endoleaks (p<0.05). The variables related to demographic and anatomical data and types of devices used by the patients did not show statistical significance, except for a significant reduction in aneurysmal sac diameter (p<0.05). Conclusions None of the markers assessed showed any association with endoleak status. However, the concentrations of MMPs and TIMPs in circulation increased in all patients after EVAR. Collectively, these findings suggest that the markers assessed have little potential to influence current post-EVAR monitoring practices. |
| format | Article |
| id | doaj-art-d1e31d2feaea4c5c81920174d21e7139 |
| institution | DOAJ |
| issn | 1677-7301 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) |
| record_format | Article |
| series | Jornal Vascular Brasileiro |
| spelling | doaj-art-d1e31d2feaea4c5c81920174d21e71392025-08-20T03:11:32ZengSociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)Jornal Vascular Brasileiro1677-73012025-05-012410.1590/1677-5449.202401631Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysmsTúlio Fabiano de Oliveira Leitehttps://orcid.org/0000-0001-9427-5897Elpidio Ribeiro da SilvaKaroline Gomeshttps://orcid.org/0000-0001-6881-0024Daniela Pretti da Cunha Tirapellihttps://orcid.org/0000-0002-1886-4988Edwaldo Edner Jovilianohttps://orcid.org/0000-0001-7237-4771Abstract Background Endovascular aneurysm repair (EVAR) is now considered the preferred treatment modality in most abdominal aortic aneurysm (AAA) patients. Objectives The objective of this study was to quantify and evaluate MMP-2, MMP-9, TIMP-1, and TIMP-2 expression response to EVAR based on serum assays at 6-month follow-up. Methods 47 patients with AAA who underwent EVAR and ten people with no comorbidities were recruited for the study. Plasma levels of MMPs and TIMPs were assayed by ELISA preoperatively and after 6 months in the group submitted to EVAR and only once in the control group. Demographic profiles, clinical follow-up data, and imaging exams with angiotomography performed preoperatively and after 6 months were collected. Results Forty-seven patients with AAA were treated with EVAR. 87.2% of these patients were male and 68.08% were smokers. There were no deaths in the first 30 days. Ten patients (21.27%) had an endoleak during the 6-month postoperative period. Higher MMP and TIMP levels were observed in the AAA patients compared with patients in the control group, although without statistical significance. After EVAR, there were increases in MMP and TIMP levels both in the group with endoleaks and in the group without endoleaks (p<0.05). The variables related to demographic and anatomical data and types of devices used by the patients did not show statistical significance, except for a significant reduction in aneurysmal sac diameter (p<0.05). Conclusions None of the markers assessed showed any association with endoleak status. However, the concentrations of MMPs and TIMPs in circulation increased in all patients after EVAR. Collectively, these findings suggest that the markers assessed have little potential to influence current post-EVAR monitoring practices.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492025000100312&lng=en&tlng=enabdominal aortic aneurysmendovascular aneurysm repairmatrix metalloproteinasetissue inhibitors of metaloproteinasesendoleaks |
| spellingShingle | Túlio Fabiano de Oliveira Leite Elpidio Ribeiro da Silva Karoline Gomes Daniela Pretti da Cunha Tirapelli Edwaldo Edner Joviliano Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms Jornal Vascular Brasileiro abdominal aortic aneurysm endovascular aneurysm repair matrix metalloproteinase tissue inhibitors of metaloproteinases endoleaks |
| title | Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms |
| title_full | Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms |
| title_fullStr | Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms |
| title_full_unstemmed | Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms |
| title_short | Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms |
| title_sort | expression of plasma levels of mmp 2 mmp 9 timp 1 and timp 2 in patients with abdominal aortic aneurysms |
| topic | abdominal aortic aneurysm endovascular aneurysm repair matrix metalloproteinase tissue inhibitors of metaloproteinases endoleaks |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492025000100312&lng=en&tlng=en |
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