Proteases Revisited: Roles and Therapeutic Implications in Fibrosis
Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases (i.e., pr...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/2570154 |
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| _version_ | 1849682983543373824 |
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| author | Jakub Kryczka Joanna Boncela |
| author_facet | Jakub Kryczka Joanna Boncela |
| author_sort | Jakub Kryczka |
| collection | DOAJ |
| description | Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases (i.e., proteolysis of nonactive zymogens), decomposition of cell-cell junctions, release of sequestered growth factors (TGF-β and VEGF), activation of signal proteins and receptors, degradation of inflammatory inhibitors or inflammation-related proteins, and changes in cell mechanosensing and motility. Intracellular proteases, mainly caspases and cathepsins, modulate lysosome activity and signal transduction pathways. Herein, we discuss the current knowledge on the multidimensional impact of proteases on the development of fibrosis. |
| format | Article |
| id | doaj-art-d1e2f2622ba142729d76dbd10ba7986e |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d1e2f2622ba142729d76dbd10ba7986e2025-08-20T03:24:02ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/25701542570154Proteases Revisited: Roles and Therapeutic Implications in FibrosisJakub Kryczka0Joanna Boncela1Institute of Medical Biology, Polish Academy of Sciences, Lodz, PolandInstitute of Medical Biology, Polish Academy of Sciences, Lodz, PolandProteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases (i.e., proteolysis of nonactive zymogens), decomposition of cell-cell junctions, release of sequestered growth factors (TGF-β and VEGF), activation of signal proteins and receptors, degradation of inflammatory inhibitors or inflammation-related proteins, and changes in cell mechanosensing and motility. Intracellular proteases, mainly caspases and cathepsins, modulate lysosome activity and signal transduction pathways. Herein, we discuss the current knowledge on the multidimensional impact of proteases on the development of fibrosis.http://dx.doi.org/10.1155/2017/2570154 |
| spellingShingle | Jakub Kryczka Joanna Boncela Proteases Revisited: Roles and Therapeutic Implications in Fibrosis Mediators of Inflammation |
| title | Proteases Revisited: Roles and Therapeutic Implications in Fibrosis |
| title_full | Proteases Revisited: Roles and Therapeutic Implications in Fibrosis |
| title_fullStr | Proteases Revisited: Roles and Therapeutic Implications in Fibrosis |
| title_full_unstemmed | Proteases Revisited: Roles and Therapeutic Implications in Fibrosis |
| title_short | Proteases Revisited: Roles and Therapeutic Implications in Fibrosis |
| title_sort | proteases revisited roles and therapeutic implications in fibrosis |
| url | http://dx.doi.org/10.1155/2017/2570154 |
| work_keys_str_mv | AT jakubkryczka proteasesrevisitedrolesandtherapeuticimplicationsinfibrosis AT joannaboncela proteasesrevisitedrolesandtherapeuticimplicationsinfibrosis |