Cardiovascular risk factors in patients with subclinical hypothyroidism
Background/Aims. Overt hypothyroidism is disease associated with accelerated arteriosclerosis and coronary heart disease. Whether subclinical hypothyroidism (SH) is associated with increased cardiovascular risk is contraversial. As SH is a high prevalence thyroid dysfunction, specially in older wome...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2007-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500711749P.pdf |
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| author | Pešić Milica Antić Slobodan Kocić Radivoj Radojković Danijela Radenković Saša |
| author_facet | Pešić Milica Antić Slobodan Kocić Radivoj Radojković Danijela Radenković Saša |
| author_sort | Pešić Milica |
| collection | DOAJ |
| description | Background/Aims. Overt hypothyroidism is disease associated with accelerated arteriosclerosis and coronary heart disease. Whether subclinical hypothyroidism (SH) is associated with increased cardiovascular risk is contraversial. As SH is a high prevalence thyroid dysfunction, specially in older women, it is important to evaluate cardiovascular risk factors in these patients and that was the aim of this study. Methods. We examined 30 patients with SH and 20 healthy controls. Subclinical hypothireoidism was defined as an elevated thyrotropin (TSH) (> 4.5 mU/L) and normal free thyroxine (FT4) level. In all the participants we determined body mass index (BMI), blood pressure, TSH, FT4, antibodies to thyroid peroxidase, antibodies to thyroglobulin, total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglicerides, total cholesterol/HDL cholesterol ratio and LDL/HDL cholesterol ratio. Results. Mean BMI in patients with SH was significantly higher (p < 0.05), as well as diastolic blood pressure (p < 0.01) compared with the controls. Average levels of total cholesterol (5.40±0.62 vs 5.06±0.19 mmol/l, p < 0.01) and triglycerides (2.16±0.56 vs 1.89±0.24 mmol/l, p < 0.05) were also significantly higher in the group with SH. Individual analysis revealed that the percentage of patients with SH having borderline elevated total cholesterol (63.33%), hypertrigliceridemia (43.33%) and elevated total cholesterol/HDL cholesterol ratio (26.67%) were significantly higher than the percentage in the controls. No significant correlation between TSH and lipid parameters was detected. Conclusion. Subclinical hypothyroidism was associated with higher BMI, diastolic hypertension, higher total cholesterol and triglicerides levels and higher total cholesterol/HDL cholesterols ratio. This might increase the risk of accelerated arteriosclerosis in patients with SH. |
| format | Article |
| id | doaj-art-d1e1c3b0035645c7a403dcaeeb451b7f |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-d1e1c3b0035645c7a403dcaeeb451b7f2025-08-20T03:24:59ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502007-01-01641174975210.2298/VSP0711749PCardiovascular risk factors in patients with subclinical hypothyroidismPešić MilicaAntić SlobodanKocić RadivojRadojković DanijelaRadenković SašaBackground/Aims. Overt hypothyroidism is disease associated with accelerated arteriosclerosis and coronary heart disease. Whether subclinical hypothyroidism (SH) is associated with increased cardiovascular risk is contraversial. As SH is a high prevalence thyroid dysfunction, specially in older women, it is important to evaluate cardiovascular risk factors in these patients and that was the aim of this study. Methods. We examined 30 patients with SH and 20 healthy controls. Subclinical hypothireoidism was defined as an elevated thyrotropin (TSH) (> 4.5 mU/L) and normal free thyroxine (FT4) level. In all the participants we determined body mass index (BMI), blood pressure, TSH, FT4, antibodies to thyroid peroxidase, antibodies to thyroglobulin, total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglicerides, total cholesterol/HDL cholesterol ratio and LDL/HDL cholesterol ratio. Results. Mean BMI in patients with SH was significantly higher (p < 0.05), as well as diastolic blood pressure (p < 0.01) compared with the controls. Average levels of total cholesterol (5.40±0.62 vs 5.06±0.19 mmol/l, p < 0.01) and triglycerides (2.16±0.56 vs 1.89±0.24 mmol/l, p < 0.05) were also significantly higher in the group with SH. Individual analysis revealed that the percentage of patients with SH having borderline elevated total cholesterol (63.33%), hypertrigliceridemia (43.33%) and elevated total cholesterol/HDL cholesterol ratio (26.67%) were significantly higher than the percentage in the controls. No significant correlation between TSH and lipid parameters was detected. Conclusion. Subclinical hypothyroidism was associated with higher BMI, diastolic hypertension, higher total cholesterol and triglicerides levels and higher total cholesterol/HDL cholesterols ratio. This might increase the risk of accelerated arteriosclerosis in patients with SH.http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500711749P.pdfhypothyroidismarteriosclerosiscoronary arteriosclerosisrisk factorslipidscholesterol |
| spellingShingle | Pešić Milica Antić Slobodan Kocić Radivoj Radojković Danijela Radenković Saša Cardiovascular risk factors in patients with subclinical hypothyroidism Vojnosanitetski Pregled hypothyroidism arteriosclerosis coronary arteriosclerosis risk factors lipids cholesterol |
| title | Cardiovascular risk factors in patients with subclinical hypothyroidism |
| title_full | Cardiovascular risk factors in patients with subclinical hypothyroidism |
| title_fullStr | Cardiovascular risk factors in patients with subclinical hypothyroidism |
| title_full_unstemmed | Cardiovascular risk factors in patients with subclinical hypothyroidism |
| title_short | Cardiovascular risk factors in patients with subclinical hypothyroidism |
| title_sort | cardiovascular risk factors in patients with subclinical hypothyroidism |
| topic | hypothyroidism arteriosclerosis coronary arteriosclerosis risk factors lipids cholesterol |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500711749P.pdf |
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