A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms
Continued efforts have been made to enhance the antibacterial properties of root canal sealers by adding antimicrobial agents to them. This study aims to investigate the antibacterial effect of 0.15% silver nanoparticles (NAg) and 5% dimethylaminohexadecyl methacrylate (DMAHDM) when added to EndoSeq...
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MDPI AG
2025-07-01
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| Series: | Bioengineering |
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| author | Bashayer Baras Amal Almohaimede Yara Alshibani Farah Alzahrani Raseel Alageel Michael D. Weir Hockin H. K. Xu |
| author_facet | Bashayer Baras Amal Almohaimede Yara Alshibani Farah Alzahrani Raseel Alageel Michael D. Weir Hockin H. K. Xu |
| author_sort | Bashayer Baras |
| collection | DOAJ |
| description | Continued efforts have been made to enhance the antibacterial properties of root canal sealers by adding antimicrobial agents to them. This study aims to investigate the antibacterial effect of 0.15% silver nanoparticles (NAg) and 5% dimethylaminohexadecyl methacrylate (DMAHDM) when added to EndoSequence Bioceramic (BC) sealer against <i>Enterococcus faecalis</i> (<i>E. faecalis</i>) biofilm and their impact on its physical properties (flowability and film thickness). Four root canal sealers were tested for flow and film thickness properties, as well as against antibiofilm of <i>E. faecalis</i>-impregnated dentin discs, as follows: group 1: EndoSequence BC sealer only; group 2: EndoSequence BC sealer + 0.15% NAg; group 3: EndoSequence BC sealer + 5% DMAHDM; and group 4: EndoSequence BC sealer + 0.15% NAg + 5% DMAHDM. The findings show that all groups had flow and film thickness values that were in accordance with the ISO requirements. Combining 0.15% NAg and 5% DMAHDM in EndoSequence significantly reduced colony-forming unit (CFU) counts by approximately 5 logs. The combination of NAg and DMAHDM offers a promising strategy for developing endodontic sealers with improved antimicrobial properties and acceptable physical performance. |
| format | Article |
| id | doaj-art-d1e0fefb6ae544b282c5d636a0e3cf2d |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Bioengineering |
| spelling | doaj-art-d1e0fefb6ae544b282c5d636a0e3cf2d2025-08-20T03:58:31ZengMDPI AGBioengineering2306-53542025-07-0112776810.3390/bioengineering12070768A Modified Bioceramic Sealer with Dual Antibacterial MechanismsBashayer Baras0Amal Almohaimede1Yara Alshibani2Farah Alzahrani3Raseel Alageel4Michael D. Weir5Hockin H. K. Xu6Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11432, Saudi ArabiaDepartment of Restorative Dental Science, Endodontic Division, College of Dentistry, King Saud University, Riyadh 11432, Saudi ArabiaCollege of Dentistry, King Saud University, Riyadh 11432, Saudi ArabiaCollege of Dentistry, King Saud University, Riyadh 11432, Saudi ArabiaCare Medical Hospital, Riyadh 14214, Saudi ArabiaDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USADepartment of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USAContinued efforts have been made to enhance the antibacterial properties of root canal sealers by adding antimicrobial agents to them. This study aims to investigate the antibacterial effect of 0.15% silver nanoparticles (NAg) and 5% dimethylaminohexadecyl methacrylate (DMAHDM) when added to EndoSequence Bioceramic (BC) sealer against <i>Enterococcus faecalis</i> (<i>E. faecalis</i>) biofilm and their impact on its physical properties (flowability and film thickness). Four root canal sealers were tested for flow and film thickness properties, as well as against antibiofilm of <i>E. faecalis</i>-impregnated dentin discs, as follows: group 1: EndoSequence BC sealer only; group 2: EndoSequence BC sealer + 0.15% NAg; group 3: EndoSequence BC sealer + 5% DMAHDM; and group 4: EndoSequence BC sealer + 0.15% NAg + 5% DMAHDM. The findings show that all groups had flow and film thickness values that were in accordance with the ISO requirements. Combining 0.15% NAg and 5% DMAHDM in EndoSequence significantly reduced colony-forming unit (CFU) counts by approximately 5 logs. The combination of NAg and DMAHDM offers a promising strategy for developing endodontic sealers with improved antimicrobial properties and acceptable physical performance.https://www.mdpi.com/2306-5354/12/7/768antibacterial agentsDMAHDMendodonticsinnovative materialssilver nanoparticlesphysical properties |
| spellingShingle | Bashayer Baras Amal Almohaimede Yara Alshibani Farah Alzahrani Raseel Alageel Michael D. Weir Hockin H. K. Xu A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms Bioengineering antibacterial agents DMAHDM endodontics innovative materials silver nanoparticles physical properties |
| title | A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms |
| title_full | A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms |
| title_fullStr | A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms |
| title_full_unstemmed | A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms |
| title_short | A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms |
| title_sort | modified bioceramic sealer with dual antibacterial mechanisms |
| topic | antibacterial agents DMAHDM endodontics innovative materials silver nanoparticles physical properties |
| url | https://www.mdpi.com/2306-5354/12/7/768 |
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