Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors
Abstract In gastrointestinal tumor treatment, conventional therapies are often limited by challenges such as tumor heterogeneity, high invasiveness, and recurrence rat. In recent years, sonodynamic therapy (SDT) has emerged as a promising alternative, leveraging sonosensitizers and ultrasound to dis...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02810-x |
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| author | Menghan Gui Xinmei Zheng Hexin Fu Mingming Cang Haokai Ma Jingshu He Dong Tang |
| author_facet | Menghan Gui Xinmei Zheng Hexin Fu Mingming Cang Haokai Ma Jingshu He Dong Tang |
| author_sort | Menghan Gui |
| collection | DOAJ |
| description | Abstract In gastrointestinal tumor treatment, conventional therapies are often limited by challenges such as tumor heterogeneity, high invasiveness, and recurrence rat. In recent years, sonodynamic therapy (SDT) has emerged as a promising alternative, leveraging sonosensitizers and ultrasound to disrupt cancer cells through microbubble vibrations, singlet oxygen generation, and immunogenic cell death. SDT also inhibits tumor vasculature and angiogenesis, enhancing its efficacy. However, the clinical application of SDT is currently hindered by limitations, such as poor water solubility and susceptibility to hypoxic tumor environments. Nanomaterial carriers, such as zeolitic imidazolate frameworks (ZIF-8), address these issues by targeting reactive oxygen species release and activating chemotherapeutic agents like tirapazamine (TPZ), improving therapeutic outcomes and safety. This review explores the fundamental principles of SDT, its integration with nanomaterials, and future directions in gastrointestinal tumor treatment. |
| format | Article |
| id | doaj-art-d1e0efa47add4de1bee600ef283c82ac |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-d1e0efa47add4de1bee600ef283c82ac2025-08-20T04:01:36ZengSpringerDiscover Oncology2730-60112025-07-0116112010.1007/s12672-025-02810-xApplications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumorsMenghan Gui0Xinmei Zheng1Hexin Fu2Mingming Cang3Haokai Ma4Jingshu He5Dong Tang6Yangzhou University, Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhou University, Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhou University, Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhou University, Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityXuzhou Medical University, Northern Jiangsu People’s Hospital Affiliated to Xuzhou Medical UniversityClinical Teaching Hospital of Medicine School, Nanjing University, Northern Jiangsu People’s HospitalDepartment of General Surgery, Institute of General Surgery, Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityAbstract In gastrointestinal tumor treatment, conventional therapies are often limited by challenges such as tumor heterogeneity, high invasiveness, and recurrence rat. In recent years, sonodynamic therapy (SDT) has emerged as a promising alternative, leveraging sonosensitizers and ultrasound to disrupt cancer cells through microbubble vibrations, singlet oxygen generation, and immunogenic cell death. SDT also inhibits tumor vasculature and angiogenesis, enhancing its efficacy. However, the clinical application of SDT is currently hindered by limitations, such as poor water solubility and susceptibility to hypoxic tumor environments. Nanomaterial carriers, such as zeolitic imidazolate frameworks (ZIF-8), address these issues by targeting reactive oxygen species release and activating chemotherapeutic agents like tirapazamine (TPZ), improving therapeutic outcomes and safety. This review explores the fundamental principles of SDT, its integration with nanomaterials, and future directions in gastrointestinal tumor treatment.https://doi.org/10.1007/s12672-025-02810-xSonodynamic therapySonosensitizersNanomaterialsGastrointestinal tumorsImmunotherapyCombination therapy |
| spellingShingle | Menghan Gui Xinmei Zheng Hexin Fu Mingming Cang Haokai Ma Jingshu He Dong Tang Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors Discover Oncology Sonodynamic therapy Sonosensitizers Nanomaterials Gastrointestinal tumors Immunotherapy Combination therapy |
| title | Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors |
| title_full | Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors |
| title_fullStr | Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors |
| title_full_unstemmed | Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors |
| title_short | Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors |
| title_sort | applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors |
| topic | Sonodynamic therapy Sonosensitizers Nanomaterials Gastrointestinal tumors Immunotherapy Combination therapy |
| url | https://doi.org/10.1007/s12672-025-02810-x |
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