Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study
Objectives Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults.Design We conducted a population-based matched...
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BMJ Publishing Group
2021-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/12/e053133.full |
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| author | Juha Pekkanen Jussi Karjalainen Jari Haukka Anna But Sanna Toppila-Salmi Riikka Lemmetyinen Risto Renkonen |
| author_facet | Juha Pekkanen Jussi Karjalainen Jari Haukka Anna But Sanna Toppila-Salmi Riikka Lemmetyinen Risto Renkonen |
| author_sort | Juha Pekkanen |
| collection | DOAJ |
| description | Objectives Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults.Design We conducted a population-based matched cohort study with a 13.8-year follow-up.Setting A baseline questionnaire was completed by participants in 1997 and follow-up data were extracted from the national hospital discharge registry of the National Institute for Health and Welfare in Finland from 1997 to 2014.Participants A total of 1394 adults with asthma were matched with 2398 adults without asthma based on sex, age and area of residence. Asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right resulting from asthma. Participants without asthma were identified from the Population Register.Main outcomes and measures Oral health-related primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition and divided into groups of diseases. Cox’s proportional hazards models stratified by matching unit and models matched and adjusted for pack-years, education level and body mass index (when possible) were used to evaluate the matched and further adjusted HRs for diseases comparing asthmatic and non-asthmatic cohorts.Results Adult asthma was associated with a higher risk for any oral-manifesting disease (adjusted HR 1.41, 95% CI 1.11 to 1.80), herpes zoster (adjusted HR 6.18, 95% CI 1.21 to 31.6), benign tumours of the oral cavity and pharynx (matched HR 1.94, 95% CI 1.05 to 3.56) and dermatological diseases (pemphigus, pemphigoid, dermatitis herpetiformis, psoriasis and lichen planus, HR 1.67, 95% CI 1.01 to 2.78).Conclusions In this study, adult asthmatics experienced a higher risk for a major oral disease or oral-manifesting disease. |
| format | Article |
| id | doaj-art-d1db33b2994044658c7f8528bc451c60 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d1db33b2994044658c7f8528bc451c602024-12-10T21:50:10ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2021-053133Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort studyJuha Pekkanen0Jussi Karjalainen1Jari Haukka2Anna But3Sanna Toppila-Salmi4Riikka Lemmetyinen5Risto Renkonen6Finnish Institute for Health and Welfare, Helsinki, Uusimaa, FinlandAllergy Centre, University of Tampere, Tampere, Pirkanmaa, FinlandFaculty of Medicine and Health Technology, Tampere University, Tampere, FinlandDepartment of Public Health, University of Helsinki, Helsinki, Uusimaa, FinlandSkin and Allergy Hospital, Helsinki, Uusimaa, FinlandHaartman Institute, University of Helsinki, Helsinki, Uusimaa, FinlandHaartman Institute, University of Helsinki, Helsinki, FinlandObjectives Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults.Design We conducted a population-based matched cohort study with a 13.8-year follow-up.Setting A baseline questionnaire was completed by participants in 1997 and follow-up data were extracted from the national hospital discharge registry of the National Institute for Health and Welfare in Finland from 1997 to 2014.Participants A total of 1394 adults with asthma were matched with 2398 adults without asthma based on sex, age and area of residence. Asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right resulting from asthma. Participants without asthma were identified from the Population Register.Main outcomes and measures Oral health-related primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition and divided into groups of diseases. Cox’s proportional hazards models stratified by matching unit and models matched and adjusted for pack-years, education level and body mass index (when possible) were used to evaluate the matched and further adjusted HRs for diseases comparing asthmatic and non-asthmatic cohorts.Results Adult asthma was associated with a higher risk for any oral-manifesting disease (adjusted HR 1.41, 95% CI 1.11 to 1.80), herpes zoster (adjusted HR 6.18, 95% CI 1.21 to 31.6), benign tumours of the oral cavity and pharynx (matched HR 1.94, 95% CI 1.05 to 3.56) and dermatological diseases (pemphigus, pemphigoid, dermatitis herpetiformis, psoriasis and lichen planus, HR 1.67, 95% CI 1.01 to 2.78).Conclusions In this study, adult asthmatics experienced a higher risk for a major oral disease or oral-manifesting disease.https://bmjopen.bmj.com/content/11/12/e053133.full |
| spellingShingle | Juha Pekkanen Jussi Karjalainen Jari Haukka Anna But Sanna Toppila-Salmi Riikka Lemmetyinen Risto Renkonen Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study BMJ Open |
| title | Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study |
| title_full | Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study |
| title_fullStr | Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study |
| title_full_unstemmed | Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study |
| title_short | Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study |
| title_sort | diseases with oral manifestations among adult asthmatics in finland a population based matched cohort study |
| url | https://bmjopen.bmj.com/content/11/12/e053133.full |
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