Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma
Purpose. To perform multivariate analysis for identifying independent predictors of elevated intraocular pressure (IOP) with neovascular glaucoma (NVG), including antivascular endothelial growth factor (VEGF) intravitreal injections. Methods. We retrospectively reviewed 142 NVG patients (181 eyes) w...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/1205895 |
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| author | Satoko Nakano Takako Nakamuro Katsuhiko Yokoyama Kunihiro Kiyosaki Toshiaki Kubota |
| author_facet | Satoko Nakano Takako Nakamuro Katsuhiko Yokoyama Kunihiro Kiyosaki Toshiaki Kubota |
| author_sort | Satoko Nakano |
| collection | DOAJ |
| description | Purpose. To perform multivariate analysis for identifying independent predictors of elevated intraocular pressure (IOP) with neovascular glaucoma (NVG), including antivascular endothelial growth factor (VEGF) intravitreal injections. Methods. We retrospectively reviewed 142 NVG patients (181 eyes) with ischemic retinal diseases [proliferative diabetic retinopathy (PDR) in 134 eyes, retinal vein occlusion (RVO) in 29, and ocular ischemic syndrome in 18]. We analyzed age, gender, initial/final LogMAR VA, initial/final IOP, extent of iris and/or angle neovascularization, treatments, preexisting complications, concurrent medications, and follow-up duration. Results. The mean follow-up duration was 23.8 ± 18.8 months. At the final follow-up, 125 (72.3%) eyes had IOP ≤ 21 mmHg. NVG patients with RVO had a higher degree of angle closure and higher IOP. NVG with PDR had better IOP and LogMAR VA. Angle closure had the greatest impact on final IOP. Greater than 90% of patients treated with trabeculectomy with mitomycin C (LEC) had persistent declines in IOP (≤21 mmHg). Stand-alone and combination anti-VEGF therapies were not associated with improved long-term prognosis of IOP. Conclusions. Angle closure was found to have the greatest effect on NVG-IOP prognosis. When target IOP values are not obtained after adequate PRP with or without anti-VEGF, early LEC may improve the prognosis of IOP. |
| format | Article |
| id | doaj-art-d1d5e69ff32c497796635cab2dbd2b68 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-d1d5e69ff32c497796635cab2dbd2b682025-02-03T05:58:14ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/12058951205895Prognostic Factor Analysis of Intraocular Pressure with Neovascular GlaucomaSatoko Nakano0Takako Nakamuro1Katsuhiko Yokoyama2Kunihiro Kiyosaki3Toshiaki Kubota4Department of Ophthalmology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, JapanDepartment of Ophthalmology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, JapanDepartment of Ophthalmology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, JapanDepartment of Ophthalmology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, JapanDepartment of Ophthalmology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, JapanPurpose. To perform multivariate analysis for identifying independent predictors of elevated intraocular pressure (IOP) with neovascular glaucoma (NVG), including antivascular endothelial growth factor (VEGF) intravitreal injections. Methods. We retrospectively reviewed 142 NVG patients (181 eyes) with ischemic retinal diseases [proliferative diabetic retinopathy (PDR) in 134 eyes, retinal vein occlusion (RVO) in 29, and ocular ischemic syndrome in 18]. We analyzed age, gender, initial/final LogMAR VA, initial/final IOP, extent of iris and/or angle neovascularization, treatments, preexisting complications, concurrent medications, and follow-up duration. Results. The mean follow-up duration was 23.8 ± 18.8 months. At the final follow-up, 125 (72.3%) eyes had IOP ≤ 21 mmHg. NVG patients with RVO had a higher degree of angle closure and higher IOP. NVG with PDR had better IOP and LogMAR VA. Angle closure had the greatest impact on final IOP. Greater than 90% of patients treated with trabeculectomy with mitomycin C (LEC) had persistent declines in IOP (≤21 mmHg). Stand-alone and combination anti-VEGF therapies were not associated with improved long-term prognosis of IOP. Conclusions. Angle closure was found to have the greatest effect on NVG-IOP prognosis. When target IOP values are not obtained after adequate PRP with or without anti-VEGF, early LEC may improve the prognosis of IOP.http://dx.doi.org/10.1155/2016/1205895 |
| spellingShingle | Satoko Nakano Takako Nakamuro Katsuhiko Yokoyama Kunihiro Kiyosaki Toshiaki Kubota Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma Journal of Ophthalmology |
| title | Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma |
| title_full | Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma |
| title_fullStr | Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma |
| title_full_unstemmed | Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma |
| title_short | Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma |
| title_sort | prognostic factor analysis of intraocular pressure with neovascular glaucoma |
| url | http://dx.doi.org/10.1155/2016/1205895 |
| work_keys_str_mv | AT satokonakano prognosticfactoranalysisofintraocularpressurewithneovascularglaucoma AT takakonakamuro prognosticfactoranalysisofintraocularpressurewithneovascularglaucoma AT katsuhikoyokoyama prognosticfactoranalysisofintraocularpressurewithneovascularglaucoma AT kunihirokiyosaki prognosticfactoranalysisofintraocularpressurewithneovascularglaucoma AT toshiakikubota prognosticfactoranalysisofintraocularpressurewithneovascularglaucoma |