Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease
Human T follicular helper (Tfh) cells play a crucial role in orchestrating B cell differentiation, maturation, and immunoglobulin class switching. Recent studies have underscored the presence of Bcl-6 + Tfh cells not only in secondary lymphoid organs but also within tertiary lymphoid structures at i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893024000789 |
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| author | Mitsuhiro Akiyama Waleed Alshehri Sho Ishigaki Koichi Saito Yuko Kaneko |
| author_facet | Mitsuhiro Akiyama Waleed Alshehri Sho Ishigaki Koichi Saito Yuko Kaneko |
| author_sort | Mitsuhiro Akiyama |
| collection | DOAJ |
| description | Human T follicular helper (Tfh) cells play a crucial role in orchestrating B cell differentiation, maturation, and immunoglobulin class switching. Recent studies have underscored the presence of Bcl-6 + Tfh cells not only in secondary lymphoid organs but also within tertiary lymphoid structures at inflammatory sites, emphasizing their pivotal role in disease pathogenesis. Furthermore, Tfh cells have been found to transit between lesion sites, lymph nodes, and peripheral blood, as revealed by T cell receptor repertoire analysis. Among Tfh subsets, Tfh2 cells have emerged as central orchestrators in driving the production of IgE and IgG4 from B cells. Their critical role in diseases such as allergy, malignancy, and IgG4-related disease highlights their profound impact on balancing inflammation and immune tolerance. Our current review provides the molecular characteristics of human Tfh cells, the differentiation pathways of Tfh subsets, mechanisms by which Tfh subsets induce IgE and IgG4 production, and their clinical implications in allergy, malignancy, and IgG4-related disease. |
| format | Article |
| id | doaj-art-d1d5cdaa6ff74caa9c870d4be08c7748 |
| institution | Kabale University |
| issn | 1323-8930 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj-art-d1d5cdaa6ff74caa9c870d4be08c77482025-01-04T04:56:05ZengElsevierAllergology International1323-89302025-01-017412532Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related diseaseMitsuhiro Akiyama0Waleed Alshehri1Sho Ishigaki2Koichi Saito3Yuko Kaneko4Corresponding author. Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanHuman T follicular helper (Tfh) cells play a crucial role in orchestrating B cell differentiation, maturation, and immunoglobulin class switching. Recent studies have underscored the presence of Bcl-6 + Tfh cells not only in secondary lymphoid organs but also within tertiary lymphoid structures at inflammatory sites, emphasizing their pivotal role in disease pathogenesis. Furthermore, Tfh cells have been found to transit between lesion sites, lymph nodes, and peripheral blood, as revealed by T cell receptor repertoire analysis. Among Tfh subsets, Tfh2 cells have emerged as central orchestrators in driving the production of IgE and IgG4 from B cells. Their critical role in diseases such as allergy, malignancy, and IgG4-related disease highlights their profound impact on balancing inflammation and immune tolerance. Our current review provides the molecular characteristics of human Tfh cells, the differentiation pathways of Tfh subsets, mechanisms by which Tfh subsets induce IgE and IgG4 production, and their clinical implications in allergy, malignancy, and IgG4-related disease.http://www.sciencedirect.com/science/article/pii/S1323893024000789AllergyIgEIgG4IgG4-related diseaseMalignancy |
| spellingShingle | Mitsuhiro Akiyama Waleed Alshehri Sho Ishigaki Koichi Saito Yuko Kaneko Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease Allergology International Allergy IgE IgG4 IgG4-related disease Malignancy |
| title | Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease |
| title_full | Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease |
| title_fullStr | Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease |
| title_full_unstemmed | Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease |
| title_short | Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease |
| title_sort | human t follicular helper cells and their impact on ige and igg4 production across allergy malignancy and igg4 related disease |
| topic | Allergy IgE IgG4 IgG4-related disease Malignancy |
| url | http://www.sciencedirect.com/science/article/pii/S1323893024000789 |
| work_keys_str_mv | AT mitsuhiroakiyama humantfollicularhelpercellsandtheirimpactonigeandigg4productionacrossallergymalignancyandigg4relateddisease AT waleedalshehri humantfollicularhelpercellsandtheirimpactonigeandigg4productionacrossallergymalignancyandigg4relateddisease AT shoishigaki humantfollicularhelpercellsandtheirimpactonigeandigg4productionacrossallergymalignancyandigg4relateddisease AT koichisaito humantfollicularhelpercellsandtheirimpactonigeandigg4productionacrossallergymalignancyandigg4relateddisease AT yukokaneko humantfollicularhelpercellsandtheirimpactonigeandigg4productionacrossallergymalignancyandigg4relateddisease |