Immunologic changes in the peripheral blood transcriptome of individuals with early-stage chronic Chagas cardiomyopathy: a cross-sectional studyResearch in context

Immunologic changes in the peripheral blood transcriptome of individuals with early-stage chronic Chagas cardiomyopathy: a cross-sectional studyResearch in context

Summary: Background: Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a neglected disease that affects approximately 6 million individuals worldwide. Of those infected, 20–30% will go on to develop chronic Chagas cardiomyopathy (CCC), and many ultimately to advanced heart fail...

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Bibliographic Details
Main Authors: Carolina Duque, Jaime So, Yagahira E. Castro-Sesquen, Kelly DeToy, Sneider A. Gutierrez Guarnizo, Fatemeh Jahanbakhsh, Edith Malaga Machaca, Monica Miranda-Schaeubinger, Indira Chakravarti, Virginia Cooper, Mary E. Schmidt, Luigi Adamo, Rachel Marcus, Kawsar R. Talaat, Robert H. Gilman, Monica R. Mugnier
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:The Lancet Regional Health. Americas
Subjects:
Chagas
Cardiomyopathy
Gene expression
Immune
Biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2667193X25001000
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