The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism
Polycystic ovary syndrome (PCOS), a prevalent reproductive endocrine and metabolic disorder in gynecology, has hyperandrogenism (HA) as an essential pathophysiological alteration. PCOS patients, with or without HA, present diverse clinical manifestations. The function of intestinal or reproductive t...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2025-06-01
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| Series: | Endocrine Connections |
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| Online Access: | https://ec.bioscientifica.com/view/journals/ec/14/6/EC-25-0162.xml |
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| author | Xueming Huang Liuyan Wu Yunxiang Zhang Xiaowen Lai Dan Sun |
| author_facet | Xueming Huang Liuyan Wu Yunxiang Zhang Xiaowen Lai Dan Sun |
| author_sort | Xueming Huang |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS), a prevalent reproductive endocrine and metabolic disorder in gynecology, has hyperandrogenism (HA) as an essential pathophysiological alteration. PCOS patients, with or without HA, present diverse clinical manifestations. The function of intestinal or reproductive tract microorganisms in PCOS has drawn attention in recent years and is associated with the occurrence of HA. In this article, we review the connection between the microbial alterations in the intestinal and reproductive tracts and androgens in PCOS, and elaborate on the role of TLRs in this process. |
| format | Article |
| id | doaj-art-d1d320669c5b48a8bf0dcfe04b35c503 |
| institution | Kabale University |
| issn | 2049-3614 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj-art-d1d320669c5b48a8bf0dcfe04b35c5032025-08-20T03:26:34ZengBioscientificaEndocrine Connections2049-36142025-06-0114610.1530/EC-25-01621The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolismXueming Huang0Liuyan Wu1Yunxiang Zhang2Xiaowen Lai3Dan Sun4Guangxi Medical University, Nanning, Guangxi, ChinaGuangxi Medical University, Nanning, Guangxi, ChinaGuangxi Medical University, Nanning, Guangxi, ChinaGuangxi Medical University, Nanning, Guangxi, ChinaGuangxi Medical University, Nanning, Guangxi, ChinaPolycystic ovary syndrome (PCOS), a prevalent reproductive endocrine and metabolic disorder in gynecology, has hyperandrogenism (HA) as an essential pathophysiological alteration. PCOS patients, with or without HA, present diverse clinical manifestations. The function of intestinal or reproductive tract microorganisms in PCOS has drawn attention in recent years and is associated with the occurrence of HA. In this article, we review the connection between the microbial alterations in the intestinal and reproductive tracts and androgens in PCOS, and elaborate on the role of TLRs in this process.https://ec.bioscientifica.com/view/journals/ec/14/6/EC-25-0162.xmlpolycystic ovary syndrome (pcos)microbiotaandrogentoll-like receptors (tlrs) |
| spellingShingle | Xueming Huang Liuyan Wu Yunxiang Zhang Xiaowen Lai Dan Sun The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism Endocrine Connections polycystic ovary syndrome (pcos) microbiota androgen toll-like receptors (tlrs) |
| title | The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism |
| title_full | The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism |
| title_fullStr | The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism |
| title_full_unstemmed | The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism |
| title_short | The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism |
| title_sort | role of microbiota and toll like receptors in polycystic ovary syndrome regulatory mechanisms of androgen metabolism |
| topic | polycystic ovary syndrome (pcos) microbiota androgen toll-like receptors (tlrs) |
| url | https://ec.bioscientifica.com/view/journals/ec/14/6/EC-25-0162.xml |
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