Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway
For pets, healthy hair not only represents their beautiful appearance, but also reflects their overall health status. Nutritional imbalance, skin parasites, and stress can all cause a large amount of hair loss in pets, leading to skin-related diseases and posing a threat to their health. So, it is v...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1486201/full |
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| _version_ | 1825202101600387072 |
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| author | Xue Sun Yan Ma Yi Gao Jiaxi Li Yunliang Li Yunliang Li Lei Lv |
| author_facet | Xue Sun Yan Ma Yi Gao Jiaxi Li Yunliang Li Yunliang Li Lei Lv |
| author_sort | Xue Sun |
| collection | DOAJ |
| description | For pets, healthy hair not only represents their beautiful appearance, but also reflects their overall health status. Nutritional imbalance, skin parasites, and stress can all cause a large amount of hair loss in pets, leading to skin-related diseases and posing a threat to their health. So, it is very important to understand and find solutions to alleviate or treat pet hair loss. The Wnt/β-catenin signal plays a core role in the hair regeneration process. Here, we report that keratin hydrolyzed, egg yolk lecithin, and fish collagen peptide promote β-catenin nuclear translocation and significantly enhance the expression of their target genes in canines and cats skin cell lines, indicating that these nutrients are likely to play a beneficial role in promoting hair regeneration in canines and cats. |
| format | Article |
| id | doaj-art-d1d1b31466494a18bbcd995d694f590b |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-d1d1b31466494a18bbcd995d694f590b2025-02-07T15:07:29ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-02-011210.3389/fvets.2025.14862011486201Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathwayXue Sun0Yan Ma1Yi Gao2Jiaxi Li3Yunliang Li4Yunliang Li5Lei Lv6Nourse Centre for Pet Nutrition, Wuhu, ChinaShanghai Chowsing Pet Products Co., Ltd., Shanghai, ChinaShanghai Chowsing Pet Products Co., Ltd., Shanghai, ChinaWuhu Weishi Biotechnology Co., Ltd., Wuhu, ChinaNourse Centre for Pet Nutrition, Wuhu, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, ChinaNourse Centre for Pet Nutrition, Wuhu, ChinaFor pets, healthy hair not only represents their beautiful appearance, but also reflects their overall health status. Nutritional imbalance, skin parasites, and stress can all cause a large amount of hair loss in pets, leading to skin-related diseases and posing a threat to their health. So, it is very important to understand and find solutions to alleviate or treat pet hair loss. The Wnt/β-catenin signal plays a core role in the hair regeneration process. Here, we report that keratin hydrolyzed, egg yolk lecithin, and fish collagen peptide promote β-catenin nuclear translocation and significantly enhance the expression of their target genes in canines and cats skin cell lines, indicating that these nutrients are likely to play a beneficial role in promoting hair regeneration in canines and cats.https://www.frontiersin.org/articles/10.3389/fvets.2025.1486201/fullkeratin hydrolyzedegg yolk lecithinfish collagen peptideβ-cateninhair regeneration process |
| spellingShingle | Xue Sun Yan Ma Yi Gao Jiaxi Li Yunliang Li Yunliang Li Lei Lv Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway Frontiers in Veterinary Science keratin hydrolyzed egg yolk lecithin fish collagen peptide β-catenin hair regeneration process |
| title | Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway |
| title_full | Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway |
| title_fullStr | Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway |
| title_full_unstemmed | Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway |
| title_short | Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway |
| title_sort | nutrients regulation of skin cells from canines and cats via wnt β catenin signaling pathway |
| topic | keratin hydrolyzed egg yolk lecithin fish collagen peptide β-catenin hair regeneration process |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1486201/full |
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