Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa.
Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined t...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-03-01
|
| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009397&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181530192707584 |
|---|---|
| author | Arnaud Bataille Habib Salami Ismaila Seck Modou Moustapha Lo Aminata Ba Mariame Diop Baba Sall Coumba Faye Mbargou Lo Lanceï Kaba Youssouf Sidime Mohamed Keyra Alpha Oumar Sily Diallo Mamadou Niang Cheick Abou Kounta Sidibe Amadou Sery Martin Dakouo Ahmed Bezeid El Mamy Ahmed Salem El Arbi Yahya Barry Ekaterina Isselmou Habiboullah Habiboullah Abdellahi Salem Lella Baba Doumbia Mohamed Baba Gueya Caroline Coste Cécile Squarzoni Diaw Olivier Kwiatek Geneviève Libeau Andrea Apolloni |
| author_facet | Arnaud Bataille Habib Salami Ismaila Seck Modou Moustapha Lo Aminata Ba Mariame Diop Baba Sall Coumba Faye Mbargou Lo Lanceï Kaba Youssouf Sidime Mohamed Keyra Alpha Oumar Sily Diallo Mamadou Niang Cheick Abou Kounta Sidibe Amadou Sery Martin Dakouo Ahmed Bezeid El Mamy Ahmed Salem El Arbi Yahya Barry Ekaterina Isselmou Habiboullah Habiboullah Abdellahi Salem Lella Baba Doumbia Mohamed Baba Gueya Caroline Coste Cécile Squarzoni Diaw Olivier Kwiatek Geneviève Libeau Andrea Apolloni |
| author_sort | Arnaud Bataille |
| collection | DOAJ |
| description | Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential "hotspots" for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility. |
| format | Article |
| id | doaj-art-d1cf263fec7347389a7e0a39356db907 |
| institution | OA Journals |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-d1cf263fec7347389a7e0a39356db9072025-08-20T02:17:53ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742021-03-01173e100939710.1371/journal.ppat.1009397Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa.Arnaud BatailleHabib SalamiIsmaila SeckModou Moustapha LoAminata BaMariame DiopBaba SallCoumba FayeMbargou LoLanceï KabaYoussouf SidimeMohamed KeyraAlpha Oumar Sily DialloMamadou NiangCheick Abou Kounta SidibeAmadou SeryMartin DakouoAhmed Bezeid El MamyAhmed Salem El ArbiYahya BarryEkaterina IsselmouHabiboullah HabiboullahAbdellahi Salem LellaBaba DoumbiaMohamed Baba GueyaCaroline CosteCécile Squarzoni DiawOlivier KwiatekGeneviève LibeauAndrea ApolloniPeste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential "hotspots" for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009397&type=printable |
| spellingShingle | Arnaud Bataille Habib Salami Ismaila Seck Modou Moustapha Lo Aminata Ba Mariame Diop Baba Sall Coumba Faye Mbargou Lo Lanceï Kaba Youssouf Sidime Mohamed Keyra Alpha Oumar Sily Diallo Mamadou Niang Cheick Abou Kounta Sidibe Amadou Sery Martin Dakouo Ahmed Bezeid El Mamy Ahmed Salem El Arbi Yahya Barry Ekaterina Isselmou Habiboullah Habiboullah Abdellahi Salem Lella Baba Doumbia Mohamed Baba Gueya Caroline Coste Cécile Squarzoni Diaw Olivier Kwiatek Geneviève Libeau Andrea Apolloni Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa. PLoS Pathogens |
| title | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa. |
| title_full | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa. |
| title_fullStr | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa. |
| title_full_unstemmed | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa. |
| title_short | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa. |
| title_sort | combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in west africa |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009397&type=printable |
| work_keys_str_mv | AT arnaudbataille combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT habibsalami combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT ismailaseck combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT modoumoustaphalo combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT aminataba combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT mariamediop combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT babasall combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT coumbafaye combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT mbargoulo combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT lanceikaba combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT youssoufsidime combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT mohamedkeyra combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT alphaoumarsilydiallo combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT mamadouniang combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT cheickaboukountasidibe combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT amadousery combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT martindakouo combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT ahmedbezeidelmamy combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT ahmedsalemelarbi combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT yahyabarry combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT ekaterinaisselmou combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT habiboullahhabiboullah combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT abdellahisalemlella combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT babadoumbia combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT mohamedbabagueya combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT carolinecoste combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT cecilesquarzonidiaw combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT olivierkwiatek combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT genevievelibeau combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT andreaapolloni combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica |