Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria
PURPOSEThere is limited cancer clinical research in sub-Saharan African countries despite the significant burden of cancers. The primary objective of this strengths, weaknesses, opportunities, and threats (SWOT) analysis was to understand and document factors affecting the successful implementation...
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2025-04-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO-24-00475 |
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| author | Opeyemi Bolajoko Parisa Fathi Dottington Fulwood Oluwaseyi Toye Ademola Popoola Hassan Dogo Haruna Nggada Chidiebere Ogo Omolara Fatiregun Mohammed Faruk Lateef Abiodun Anthonia Sowunmi Catherine A. Oladoyinbo Folakemi Odedina |
| author_facet | Opeyemi Bolajoko Parisa Fathi Dottington Fulwood Oluwaseyi Toye Ademola Popoola Hassan Dogo Haruna Nggada Chidiebere Ogo Omolara Fatiregun Mohammed Faruk Lateef Abiodun Anthonia Sowunmi Catherine A. Oladoyinbo Folakemi Odedina |
| author_sort | Opeyemi Bolajoko |
| collection | DOAJ |
| description | PURPOSEThere is limited cancer clinical research in sub-Saharan African countries despite the significant burden of cancers. The primary objective of this strengths, weaknesses, opportunities, and threats (SWOT) analysis was to understand and document factors affecting the successful implementation of prostate cancer (CaP) clinical research in Nigeria.METHODSThe research team used a qualitative design involving International Registry of Men with Advanced Prostate Cancer (IRONMAN) study team members as participants from four regional sites in Nigeria. One-hour listening sessions were conducted via Zoom at each site, focusing on SWOT related to the IRONMAN study. All sessions were recorded, transcribed, and analyzed. Themes were inductively coded and then synthesized across all four sites.RESULTSThe study teams identified several strengths and weaknesses in conducting the IRONMAN study at their respective sites. Key strengths included access to robust patient population for recruitment and the availability of essential resources, such as lab space, clinical knowledge, and adequate staffing. Weaknesses centered on the social determinants of health that hinder patient participation, such as transportation challenges, distance to clinics, limited access to care, and insufficient biorepository space for sample storage. A prominent opportunity identified was the potential for Nigerian institutions to engage in more clinical research, particularly multisite global trials. Threats included difficulties in retaining research staff and political instability.CONCLUSIONThis study highlights the promising research opportunities in Nigeria. The lessons learned from the IRONMAN study provide valuable insights into the feasibility of conducting CaP clinical research and trials tailored to the needs of Black men in sub-Saharan Africa. These findings offer a roadmap for future research efforts, with the potential to expand clinical trials and improve health outcomes across the region. |
| format | Article |
| id | doaj-art-d1cd72f3bc8f4bda978e0f545ff7e4c2 |
| institution | DOAJ |
| issn | 2687-8941 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj-art-d1cd72f3bc8f4bda978e0f545ff7e4c22025-08-20T03:17:32ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412025-04-011110.1200/GO-24-00475Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in NigeriaOpeyemi Bolajoko0Parisa Fathi1Dottington Fulwood2Oluwaseyi Toye3Ademola Popoola4Hassan Dogo5Haruna Nggada6Chidiebere Ogo7Omolara Fatiregun8Mohammed Faruk9Lateef Abiodun10Anthonia Sowunmi11Catherine A. Oladoyinbo12Folakemi Odedina13Mayo Clinic Comprehensive Cancer Center, Jacksonville, FLUniversity of Central Florida, Orlando, FLMayo Clinic Comprehensive Cancer Center, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLProstate Cancer Transatlantic Consortium, Jacksonville, FLMayo Clinic Comprehensive Cancer Center, Jacksonville, FLPURPOSEThere is limited cancer clinical research in sub-Saharan African countries despite the significant burden of cancers. The primary objective of this strengths, weaknesses, opportunities, and threats (SWOT) analysis was to understand and document factors affecting the successful implementation of prostate cancer (CaP) clinical research in Nigeria.METHODSThe research team used a qualitative design involving International Registry of Men with Advanced Prostate Cancer (IRONMAN) study team members as participants from four regional sites in Nigeria. One-hour listening sessions were conducted via Zoom at each site, focusing on SWOT related to the IRONMAN study. All sessions were recorded, transcribed, and analyzed. Themes were inductively coded and then synthesized across all four sites.RESULTSThe study teams identified several strengths and weaknesses in conducting the IRONMAN study at their respective sites. Key strengths included access to robust patient population for recruitment and the availability of essential resources, such as lab space, clinical knowledge, and adequate staffing. Weaknesses centered on the social determinants of health that hinder patient participation, such as transportation challenges, distance to clinics, limited access to care, and insufficient biorepository space for sample storage. A prominent opportunity identified was the potential for Nigerian institutions to engage in more clinical research, particularly multisite global trials. Threats included difficulties in retaining research staff and political instability.CONCLUSIONThis study highlights the promising research opportunities in Nigeria. The lessons learned from the IRONMAN study provide valuable insights into the feasibility of conducting CaP clinical research and trials tailored to the needs of Black men in sub-Saharan Africa. These findings offer a roadmap for future research efforts, with the potential to expand clinical trials and improve health outcomes across the region.https://ascopubs.org/doi/10.1200/GO-24-00475 |
| spellingShingle | Opeyemi Bolajoko Parisa Fathi Dottington Fulwood Oluwaseyi Toye Ademola Popoola Hassan Dogo Haruna Nggada Chidiebere Ogo Omolara Fatiregun Mohammed Faruk Lateef Abiodun Anthonia Sowunmi Catherine A. Oladoyinbo Folakemi Odedina Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria JCO Global Oncology |
| title | Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria |
| title_full | Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria |
| title_fullStr | Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria |
| title_full_unstemmed | Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria |
| title_short | Conducting Clinical Research in Low Research Resource Countries: Lessons Learned From the International Registry of Men With Advanced Prostate Cancer Study in Nigeria |
| title_sort | conducting clinical research in low research resource countries lessons learned from the international registry of men with advanced prostate cancer study in nigeria |
| url | https://ascopubs.org/doi/10.1200/GO-24-00475 |
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