Micronodular thymoma with lymphoid stroma: As benign as it sounds
Micronodular thymoma (MNT) is a rare subtype of thymoma (reported incidence is approximately 1–5%). We report a case received as a core biopsy from the “right lung mass” of a 31-year-old female. CT scan showed an 8.1 cm large well-defined mass lesion in the right middle lobe, causing indentation and...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_585_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849739336057094144 |
|---|---|
| author | Kanica Chaudhary Roshani Gala Jay Mehta |
| author_facet | Kanica Chaudhary Roshani Gala Jay Mehta |
| author_sort | Kanica Chaudhary |
| collection | DOAJ |
| description | Micronodular thymoma (MNT) is a rare subtype of thymoma (reported incidence is approximately 1–5%). We report a case received as a core biopsy from the “right lung mass” of a 31-year-old female. CT scan showed an 8.1 cm large well-defined mass lesion in the right middle lobe, causing indentation and mild compression of the right atrium. Microscopically, the biopsy showed a thymic neoplasm comprised of multiple discrete and coalescing nodules of bland epithelioid tumor cells separated by an epithelial cell-free lymphocyte-rich stroma. On immunohistochemistry, cytokeratin highlighted the thymic epithelial cells. The lymphoid cells showed a naive T-cell phenotype (TdT+ CD 3+). It is worthwhile recognizing this rare variant of thymoma as almost all the patients present with localized low stage disease with rare/no reports of recurrences or distant metastases. |
| format | Article |
| id | doaj-art-d1c4ee4812bb40a7a8ff7de26de66e65 |
| institution | DOAJ |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-d1c4ee4812bb40a7a8ff7de26de66e652025-08-20T03:06:17ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-01-01681216810.4103/ijpm.ijpm_585_23Micronodular thymoma with lymphoid stroma: As benign as it soundsKanica ChaudharyRoshani GalaJay MehtaMicronodular thymoma (MNT) is a rare subtype of thymoma (reported incidence is approximately 1–5%). We report a case received as a core biopsy from the “right lung mass” of a 31-year-old female. CT scan showed an 8.1 cm large well-defined mass lesion in the right middle lobe, causing indentation and mild compression of the right atrium. Microscopically, the biopsy showed a thymic neoplasm comprised of multiple discrete and coalescing nodules of bland epithelioid tumor cells separated by an epithelial cell-free lymphocyte-rich stroma. On immunohistochemistry, cytokeratin highlighted the thymic epithelial cells. The lymphoid cells showed a naive T-cell phenotype (TdT+ CD 3+). It is worthwhile recognizing this rare variant of thymoma as almost all the patients present with localized low stage disease with rare/no reports of recurrences or distant metastases.https://journals.lww.com/10.4103/ijpm.ijpm_585_23lung massmicronodularthymoma |
| spellingShingle | Kanica Chaudhary Roshani Gala Jay Mehta Micronodular thymoma with lymphoid stroma: As benign as it sounds Indian Journal of Pathology and Microbiology lung mass micronodular thymoma |
| title | Micronodular thymoma with lymphoid stroma: As benign as it sounds |
| title_full | Micronodular thymoma with lymphoid stroma: As benign as it sounds |
| title_fullStr | Micronodular thymoma with lymphoid stroma: As benign as it sounds |
| title_full_unstemmed | Micronodular thymoma with lymphoid stroma: As benign as it sounds |
| title_short | Micronodular thymoma with lymphoid stroma: As benign as it sounds |
| title_sort | micronodular thymoma with lymphoid stroma as benign as it sounds |
| topic | lung mass micronodular thymoma |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_585_23 |
| work_keys_str_mv | AT kanicachaudhary micronodularthymomawithlymphoidstromaasbenignasitsounds AT roshanigala micronodularthymomawithlymphoidstromaasbenignasitsounds AT jaymehta micronodularthymomawithlymphoidstromaasbenignasitsounds |