Self and parasite-derived peptides selected upon DERAA-bearing HLA-DRB1 alleles activate CD4+ T cells from Chagas cardiomyopathy patients and are associated with ventricular dysfunction

Self and parasite-derived peptides selected upon DERAA-bearing HLA-DRB1 alleles activate CD4+ T cells from Chagas cardiomyopathy patients and are associated with ventricular dysfunction

IntroductionHuman infection with the protozoan Trypanosoma cruzi causes Chagas disease, which may lead to a deadly dilated cardiomyopathy resulting from T-cell-mediated inflammation. We found that specific HLA-DRB1 alleles (*0103, *0402, *1301, and *1302) that display the DERAA motif are linked to t...

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Main Authors: Thaiany G. Souza-Silva, Eula G. A. Neves, Andrea Teixeira-Carvalho, Amanda Braga Figueiredo, Katia Luciano Pereira Morais, Juliana Apostólico, Hélcio Rodrigues, Jorge Kalil, Maria Aparecida Juliano, Luiz Juliano, Silvana Silva Araújo, Alexandre Negrão Pantaleao, Antônio Mutarelli, Maria Carmo Pereira Nunes, Kenneth J. Gollob, Walderez O. Dutra
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
Chagas disease
HLA-DRB1
cardiomyopathy
cross-reactivity
T-cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527115/full
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