circFOXP1: a potential diagnostic and therapeutic target in human diseases
Circular RNA (circRNA) are a unique class of non-coding RNAs characterized by their covalently closed loop structures, which grant them properties such as stability and conservation. Among these, circFOXP1 has been implicated in various diseases, including cancers, respiratory, skeletal, and cardiov...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1489378/full |
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| _version_ | 1850191554295103488 |
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| author | Qiang Yi Xinting Ouyang Kui Zhong Zheng Chen Weijian Zhu Gangfeng Zhu Jinghua Zhong |
| author_facet | Qiang Yi Xinting Ouyang Kui Zhong Zheng Chen Weijian Zhu Gangfeng Zhu Jinghua Zhong |
| author_sort | Qiang Yi |
| collection | DOAJ |
| description | Circular RNA (circRNA) are a unique class of non-coding RNAs characterized by their covalently closed loop structures, which grant them properties such as stability and conservation. Among these, circFOXP1 has been implicated in various diseases, including cancers, respiratory, skeletal, and cardiovascular disorders. This review systematically examines circFOXP1’s role in disease progression, highlighting its involvement in critical biological processes, including cell proliferation, invasion, apoptosis, and autophagy. Mechanistically, circFOXP1 functions through miRNA sponging, protein interactions, and modulation of key signaling pathways such as Wnt and PI3K/AKT. We discuss its potential as a diagnostic and therapeutic target. Our analysis also identifies key unresolved questions, such as the precise regulatory networks involving circFOXP1 and its translation potential, offering pathways for future research. |
| format | Article |
| id | doaj-art-d1c02b9f79ad42ed9a03b708b43ffcf3 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-d1c02b9f79ad42ed9a03b708b43ffcf32025-08-20T02:14:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14893781489378circFOXP1: a potential diagnostic and therapeutic target in human diseasesQiang Yi0Xinting Ouyang1Kui Zhong2Zheng Chen3Weijian Zhu4Gangfeng Zhu5Jinghua Zhong6The First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaCircular RNA (circRNA) are a unique class of non-coding RNAs characterized by their covalently closed loop structures, which grant them properties such as stability and conservation. Among these, circFOXP1 has been implicated in various diseases, including cancers, respiratory, skeletal, and cardiovascular disorders. This review systematically examines circFOXP1’s role in disease progression, highlighting its involvement in critical biological processes, including cell proliferation, invasion, apoptosis, and autophagy. Mechanistically, circFOXP1 functions through miRNA sponging, protein interactions, and modulation of key signaling pathways such as Wnt and PI3K/AKT. We discuss its potential as a diagnostic and therapeutic target. Our analysis also identifies key unresolved questions, such as the precise regulatory networks involving circFOXP1 and its translation potential, offering pathways for future research.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1489378/fullcircRNAcircFOXP1molecular mechanismsbiomarkertreatment target |
| spellingShingle | Qiang Yi Xinting Ouyang Kui Zhong Zheng Chen Weijian Zhu Gangfeng Zhu Jinghua Zhong circFOXP1: a potential diagnostic and therapeutic target in human diseases Frontiers in Immunology circRNA circFOXP1 molecular mechanisms biomarker treatment target |
| title | circFOXP1: a potential diagnostic and therapeutic target in human diseases |
| title_full | circFOXP1: a potential diagnostic and therapeutic target in human diseases |
| title_fullStr | circFOXP1: a potential diagnostic and therapeutic target in human diseases |
| title_full_unstemmed | circFOXP1: a potential diagnostic and therapeutic target in human diseases |
| title_short | circFOXP1: a potential diagnostic and therapeutic target in human diseases |
| title_sort | circfoxp1 a potential diagnostic and therapeutic target in human diseases |
| topic | circRNA circFOXP1 molecular mechanisms biomarker treatment target |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1489378/full |
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