Refractory Gout Attack

Refractory gout attack is an uncommon problem, since gout flares are usually self-limited. This clinical condition is characterized by serum uric acid higher than 6 mg/Dl or continuous manifestations of recurrent flares, chronic arthritis, and increased tophi. We report in this paper a 69-year-old m...

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Main Authors: Simone Fargetti, Claudia Goldenstein-Schainberg, Andressa Silva Abreu, Ricardo Fuller
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2012/657694
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author Simone Fargetti
Claudia Goldenstein-Schainberg
Andressa Silva Abreu
Ricardo Fuller
author_facet Simone Fargetti
Claudia Goldenstein-Schainberg
Andressa Silva Abreu
Ricardo Fuller
author_sort Simone Fargetti
collection DOAJ
description Refractory gout attack is an uncommon problem, since gout flares are usually self-limited. This clinical condition is characterized by serum uric acid higher than 6 mg/Dl or continuous manifestations of recurrent flares, chronic arthritis, and increased tophi. We report in this paper a 69-year-old man with a polyarticular and protracted gout attack, despite usual treatment and low urate sera levels. In order to manage this problem, we reviewed gout pathophysiology and developed a therapeutic solution based on benzbromarone pharmacokinetics. We also review herein new options for gout treatment that could be used in similar cases.
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publishDate 2012-01-01
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series Case Reports in Medicine
spelling doaj-art-d1bede2d120f45e1b599dfe402ce79782025-08-20T03:23:59ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/657694657694Refractory Gout AttackSimone Fargetti0Claudia Goldenstein-Schainberg1Andressa Silva Abreu2Ricardo Fuller3Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo (USP), Avenida Doutor Arnaldo 455, 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo (USP), Avenida Doutor Arnaldo 455, 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo (USP), Avenida Doutor Arnaldo 455, 01246-903 São Paulo, SP, BrazilRheumatology Division, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo (USP), Avenida Doutor Arnaldo 455, 01246-903 São Paulo, SP, BrazilRefractory gout attack is an uncommon problem, since gout flares are usually self-limited. This clinical condition is characterized by serum uric acid higher than 6 mg/Dl or continuous manifestations of recurrent flares, chronic arthritis, and increased tophi. We report in this paper a 69-year-old man with a polyarticular and protracted gout attack, despite usual treatment and low urate sera levels. In order to manage this problem, we reviewed gout pathophysiology and developed a therapeutic solution based on benzbromarone pharmacokinetics. We also review herein new options for gout treatment that could be used in similar cases.http://dx.doi.org/10.1155/2012/657694
spellingShingle Simone Fargetti
Claudia Goldenstein-Schainberg
Andressa Silva Abreu
Ricardo Fuller
Refractory Gout Attack
Case Reports in Medicine
title Refractory Gout Attack
title_full Refractory Gout Attack
title_fullStr Refractory Gout Attack
title_full_unstemmed Refractory Gout Attack
title_short Refractory Gout Attack
title_sort refractory gout attack
url http://dx.doi.org/10.1155/2012/657694
work_keys_str_mv AT simonefargetti refractorygoutattack
AT claudiagoldensteinschainberg refractorygoutattack
AT andressasilvaabreu refractorygoutattack
AT ricardofuller refractorygoutattack