The role of SIRT1 in the development of gastrointestinal tumors

The role of SIRT1 in the development of gastrointestinal tumors

Gastrointestinal tumors, including esophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC) and, pose significant global health challenges due to their high morbidity and mortality rates. SIRT1, an NAD+-dependent deacetylase, plays diverse roles in physiological processes and has been...

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Bibliographic Details
Main Authors: Yueming Zhang, Xiaokai Zhou, Jinghui Zhai, Jie Ma, Sixi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SIRT1
colorectal cancer
gastric cancer
tumor progression
chemoresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1606530/full
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